Epitope-based vaccination against pneumonic tularemia

被引:36
|
作者
Gregory, Stephen H. [1 ,2 ]
Mott, Stephanie [2 ]
Phung, Jennifer [2 ]
Lee, Jinhee [3 ]
Moise, Leonard [4 ,5 ]
McMurry, Julie A. [4 ]
Martin, William [4 ]
De Groot, Anne S. [4 ,5 ]
机构
[1] Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA
[2] Brown Univ, Warren Alpert Med Sch, Providence, RI 02903 USA
[3] Univ Massachusetts, Sch Med, Worcester, MA USA
[4] EpiVax Inc, Providence, RI USA
[5] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA
基金
美国国家卫生研究院;
关键词
Francisella tularensis; Lungs; DNA vaccine; FRANCISELLA-TULARENSIS LVS; TUMOR-NECROSIS-FACTOR; VIRULENT TYPE-A; PROTECTIVE IMMUNITY; INTRANASAL VACCINATION; RESPIRATORY-INFECTION; AEROSOL CHALLENGE; INTERFERON-GAMMA; FACTOR-ALPHA; STRAINS;
D O I
10.1016/j.vaccine.2009.06.101
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Francisella tularensis, the etiological agent of tularemia, is one of the most infectious bacterial pathogens known. No vaccine is currently approved for public use. Previously, we identified epitopes recognized specifically by T cells obtained from individuals following infection with E tularensis. Here, we report that a subunit vaccine constructed based upon these epitopes elicited protective immunity in "humanized" HLA class II (DRB1*0401) transgenic mice. Vaccinated mice challenged intratracheally with a lethal dose of E tularensis (Live Vaccine Strain) exhibited a rapid increase in pro-inflammatory cytokine production and diminished number of organisms in the lungs, and a concurrent increased rate of survival. These results demonstrate the efficacy of an epitope-based tularemia vaccine and suggest that such an approach might be widely applicable to the development of vaccines specific for intracellular bacterial pathogens. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5299 / 5306
页数:8
相关论文
共 50 条
  • [31] In-silico design of a multivalent epitope-based vaccine against Candida auris
    Akhtar, Nahid
    Joshi, Amit
    Kaushik, Vikas
    Kumar, Manish
    Amin-ul Mannan, M.
    MICROBIAL PATHOGENESIS, 2021, 155
  • [32] An in silico epitope-based peptide vaccine design against the 2019-nCoV
    Olanrewaju Ayodeji Durojaye
    Talifhani Mushiana
    Samuel Cosmas
    Glory Omini Ibiang
    Mercy Omini Ibiang
    Egyptian Journal of Medical Human Genetics, 21
  • [33] Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus
    Adewale Oluwaseun Fadaka
    Nicole Remaliah Samantha Sibuyi
    Darius Riziki Martin
    Mediline Goboza
    Ashwil Klein
    Abram Madimabe Madiehe
    Mervin Meyer
    Scientific Reports, 11
  • [34] In silico identification of epitope-based vaccine candidates against HTLV-1
    Jahantigh, Hamid Reza
    Stufano, Angela
    Lovreglio, Piero
    Rezaee, Seyed Abdolrahim
    Ahmadi, Khadijeh
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2022, 40 (15): : 6737 - 6754
  • [35] Novel multi epitope-based vaccine against monkeypox virus: vaccinomic approach
    Shaza W. Shantier
    Mujahed I. Mustafa
    Abdelrahman H. Abdelmoneim
    Hiba A. Fadl
    Sahar G. Elbager
    Abdelrafie M. Makhawi
    Scientific Reports, 12
  • [36] An immunoinformatics approach to epitope-based vaccine design against PspA in Streptococcus pneumoniae
    Lincon Mazumder
    Muhammad Shahab
    Saidul Islam
    Mahmuda Begum
    Jonas Ivan Nobre Oliveira
    Shamima Begum
    Shahina Akter
    Journal of Genetic Engineering and Biotechnology, 21
  • [37] Polymeric epitope-based vaccine induces protective immunity against group A Streptococcus
    Shuxiong Chen
    Victoria Ozberk
    Gayathri Sam
    Zennia Jean C. Gonzaga
    Ainslie Calcutt
    Manisha Pandey
    Michael F. Good
    Bernd H. A. Rehm
    npj Vaccines, 8
  • [38] EVALUATION OF IMMUNOGENICITY OF A NOVEL MULTI EPITOPE-BASED VACCINE AGAINST HELICOBACTER PYLORI
    Kalali, Behnam
    Wedershoven, Volker
    Mostafazadeh, Amrollah
    Wedershoven, Vincent
    Schulz, Christian
    Malfertheiner, Peter
    GASTROENTEROLOGY, 2024, 166 (05) : S438 - S438
  • [39] Development of a broad-spectrum epitope-based vaccine against Streptococcus pneumoniae
    Nahian, Md.
    Shahab, Muhammad
    Khan, Md. Rasel
    Akash, Shopnil
    Banu, Tanjina Akhtar
    Sarkar, Murshed Hasan
    Goswami, Barna
    Chowdhury, Sanjana Fatema
    Islam, Mohammad Ariful
    Abu Rus'd, Ahmed
    Begum, Shamima
    Habib, Ahashan
    Shaikh, Aftab Ali
    Nobre Oliveira, Jonas Ivan
    Akter, Shahina
    PLOS ONE, 2025, 20 (01):
  • [40] Developing T Cell Epitope-Based Vaccines Against Infection: Challenging but Worthwhile
    Tang, Xian
    Zhang, Wei
    Zhang, Zheng
    VACCINES, 2025, 13 (02)