Pulmonary Tumor Thrombotic Microangiopathy Caused by Urothelial Carcinoma Expressing Vascular Endothelial Growth Factor, Platelet-derived Growth Factor, and Osteopontin

被引：11
|
作者：
Wakabayashi, Yasushi [1 ]
Iwaya, Mai [2 ]
Akita, Mayo [1 ]
Takeuchi, Wataru [1 ]
Yamazaki, Kyohei [1 ]
Iijima, Akihiro [1 ]
机构：
[1] Nagano Prefectural Kiso Hosp, Dept Internal Med, Kiso, Japan
[2] Shinshu Univ Hosp, Dept Lab Med, Matsumoto, Nagano, Japan
来源：
INTERNAL MEDICINE | 2016年 / 55卷 / 06期
关键词：
pulmonary tumor thrombotic microangiopathy; urothelial carcinoma; vascular endothelial growth factor; platelet-derived growth factor; osteopontin; GASTRIC-CARCINOMA; TISSUE FACTOR; HYPERTENSION;
D O I：
10.2169/internalmedicine.55.5758
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal cancer-related pulmonary complication. It is generally caused by gastric adenocarcinoma, and several molecules produced by tumor cells are reported to play important roles in its pathogenesis. We herein report an autopsy case of PTTM caused by urothelial carcinoma. Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and osteopontin were found to be expressed in both the primary tumor cells and metastatic cells in the PTTM lesions. These findings implicate the possible involvement of VEGF, PDGF, and osteopontin in the pathogenesis of PTTM caused by urothelial carcinoma.
引用
收藏
页码：651 / 656
页数：6
相关论文
共 50 条
  • [21] Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension
    Wu, Kang
    Tang, Haiyang
    Lin, Ruizhu
    Carr, Shane G.
    Wang, Ziyi
    Babicheva, Aleksandra
    Ayon, Ramon J.
    Jain, Pritesh P.
    Xiong, Mingmei
    Rodriguez, Marisela
    Rahimi, Shamin
    Balistrieri, Francesca
    Rahimi, Shayan
    Valdez-Jasso, Daniela
    Simonson, Tatum S.
    Desai, Ankit A.
    Garcia, Joe G. N.
    Shyy, John Y. -J.
    Thistlethwaite, Patricia A.
    Wang, Jian
    Makino, Ayako
    Yuan, Jason X. -J.
    PULMONARY CIRCULATION, 2020, 10 (03)
  • [22] Vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression are implicated in the angiogenesis of endometrial cancer
    Seki, N
    Kodama, J
    Hongo, A
    Miyagi, Y
    Yoshinouchi, M
    Kudo, T
    EUROPEAN JOURNAL OF CANCER, 2000, 36 (01) : 68 - 73
  • [23] Platelet-Derived Growth Factor Receptor-Tyrosine Kinase Inhibitor, Imatinib, Is Effective for Treating Pulmonary Hypertension Induced by Pulmonary Tumor Thrombotic Microangiopathy
    Minatsuki, Shun
    Miura, Ichiro
    Yao, Atsushi
    Abe, Hiroyuki
    Muraoka, Hironori
    Tanaka, Mariko
    Imamura, Teruhiko
    Inaba, Toshiro
    Maki, Hisataka
    Hatano, Masaru
    Kinugawa, Koichiro
    Yao, Takashi
    Fukayama, Masashi
    Nagai, Ryozo
    Komuro, Issei
    INTERNATIONAL HEART JOURNAL, 2015, 56 (02) : 245 - 248
  • [24] Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma
    Takahashi, Fumiyuki
    Kumasaka, Toshio
    Nagaoka, Tetsutaro
    Wakiya, Midori
    Fujii, Hiroaki
    Shimizu, Kazue
    Uchida, Koji
    Morio, Yoshiteru
    Seyama, Kuniaki
    Hino, Okio
    Takahashi, Kazuhisa
    Fukuchi, Yoshinosuke
    PATHOLOGY INTERNATIONAL, 2009, 59 (10) : 752 - 756
  • [25] Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy
    Timke, Carmen
    Zieher, Heike
    Roth, Alexandra
    Hauser, Kai
    Lipson, Kenneth E.
    Weber, Klaus J.
    Debus, Juergen
    Abdollahi, Amir
    Huber, Peter E.
    CLINICAL CANCER RESEARCH, 2008, 14 (07) : 2210 - 2219
  • [26] VASCULAR ENDOTHELIAL GROWTH-FACTOR - A NEW MEMBER OF THE PLATELET-DERIVED GROWTH-FACTOR GENE FAMILY
    TISCHER, E
    GOSPODAROWICZ, D
    MITCHELL, R
    SILVA, M
    SCHILLING, J
    LAU, K
    CRISP, T
    FIDDES, JC
    ABRAHAM, JA
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (03) : 1198 - 1206
  • [27] Sequential release of vascular endothelial growth factor and platelet-derived growth factor at the appropriate time for improved angiogenesis
    Liu, Yu
    Luo, Ying
    Zhang, Jianchen
    Zhang, Lei
    Guan, Ying
    Zhang, Yongjun
    ACTA BIOMATERIALIA, 2025, 196 : 171 - 181
  • [28] Vascular endothelial growth factor A and platelet-derived growth factor play a central role in the pathogenesis of digital clubbing
    Atkinson, SR
    Fox, S
    JOURNAL OF PATHOLOGY, 2005, 207 : 53 - 53
  • [29] Comparison between Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Levels in Rhegmatogenous Retinal Detachment
    Ichsan, Andi Muhammad
    Windy, Dyah Ayu
    Muhiddin, Habibah Setyawati
    Budu
    Massi, Muhammad Nasrum
    Islam, Itzar Chaidir
    JOURNAL OF OPHTHALMOLOGY, 2021, 2021
  • [30] Vitreous and Serum Concentrations of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor in Proliferative Diabetic Retinopathy
    Muhiddin, Habibah Setyawati
    Kamaruddin, Muhammad Irfan
    Budu, Andi Muhammad Ichsan
    CLINICAL OPHTHALMOLOGY, 2020, 14 : 1547 - 1552
12345