An efficient, large-scale synthesis of cytenamide

被引：2
|
作者：
Bedford, Colin T. [1 ]
机构：
[1] UCL, Christopher Ingold Lab, Dept Chem, London WC1H 0AJ, England
来源：
JOURNAL OF CHEMICAL RESEARCH | 2018年 / 03期
关键词：
cytenamide; dibenzosuberenone; 5H-dibenzo[a; d; cyclohepten-5-one; 5H-5-chlorodibenzo[a; cycloheptene; 5H-5-cyanodibenzo[a; d]cycloheptene; d]cyclo heptene-5-carboxamide; ACID SOLVATE; INHIBITORS;
D O I：
10.3184/174751918X15218087557053
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dibenzosuberenone (5H-dibenzo[a,d] cyclohepten-5-one) was reduced to the corresponding alcohol by sodium borohydride/MeOH and converted to the corresponding 5-chloro compound by thionyl chloride/benzene, treatment of which with CuCN/toluene gave the corresponding nitrile. Hydrolysis by ethanolic KOH yielded the corresponding amide, cytenamide (5H-dibenzo[a,d]cycloheptene-5carboxamide).
引用
收藏
页码：153 / 155
页数：3
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