Association between salivary factors and cariogenic bacteria in type-2 diabetes patients

被引:4
|
作者
Almusawi, Mona A. [1 ]
Gosadi, Ibrahim [2 ]
Abidia, Randa [3 ]
Almasawi, Maram [4 ]
Alrashood, Sara T. [5 ]
Ekhzaimy, Aishah [6 ]
Alhomida, Abdullah S. [7 ]
Khan, Haseeb A. [7 ]
机构
[1] Minist Hlth, Assistant Agcy Primary Hlth Care, Res & Training Unit, Riyadh, Saudi Arabia
[2] Jazan Univ, Fac Med, Dept Family & Community Med, Jazan, Saudi Arabia
[3] Dar Al Uloom Univ, Coll Dent, Riyadh, Saudi Arabia
[4] King Saud Univ, Coll Dent, Dent Hyg Dept, Riyadh, Saudi Arabia
[5] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh, Saudi Arabia
[6] King Khalid Univ Hosp, Dept Med, Div Endocrinol, Riyadh, Saudi Arabia
[7] King Saud Univ, Coll Sci, Dept Biochem, POB 2455, Riyadh 11451, Saudi Arabia
关键词
Diabetes; Cariogenic bacteria; Saliva flow rate; Salivary glucose; Streptococcus mutans; Lactobacilli; ORAL-HEALTH STATUS; METABOLIC-CONTROL; GLYCEMIC CONTROL; DENTAL-CARIES; BLOOD-GLUCOSE; MELLITUS; INDIVIDUALS; ADULTS;
D O I
10.1016/j.jksus.2020.05.002
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Type-2 diabetes (T2DM) is a global epidemic. Among various complications of T2DM, dental caries is one of its preventable complications. This investigation was aimed to study the association between salivary factors and the growth of cariogenic bacteria in the saliva of T2DM patients. We measured the salivary glucose, saliva flow rate and its buffering capacity in T2DM patients (N = 100). Cariogenic bacteria in saliva were detected by using a Chair-side Test Kit. We also analyzed fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) in all the subjects. A large number of T2DM patients (78%) had high counts (>10(5) CFU/ml) of streptococcus mutans in their saliva whereas high counts of lactobacilli were observed only in 42% patients. We observed significant associations between streptococcus mutans load and saliva flow rate, saliva buffering capacity and glycemic control however these variable did not show any significant association with lactobacilli. Hypo-salivation, high salivary glucose and poor glycemic control promoted the growth of streptococcus mutans in the saliva of T2DM patients. In conclusion, salivary factors play important roles in controlling the salivary status of cariogenic bacteria. Thus, an adequate oral health and proper glycemic control could help in abolishing the caries risk and its complications. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码:2617 / 2621
页数:5
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