Translational PET imaging research

被引：49

作者：

Hargreaves, Richard J. ^{[1
]}

Rabiner, Eugenii A. ^{[2
,3
]}

机构：

[1] Merck & Co Inc, West Point, PA 19486 USA

[2] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Imanova Ltd Burlington, London W12 0NN, England

[3] Kings Coll London, Ctr Neurosci Imaging, London WC2R 2LS, England

来源：

NEUROBIOLOGY OF DISEASE | 2014年 / 61卷

关键词：

Positron emission tomography (PET) imaging; Drug development; Target engagement imaging; Psychiatry imaging; POSITRON-EMISSION-TOMOGRAPHY; SEROTONIN(1A) RECEPTOR-BINDING; MAJOR DEPRESSIVE DISORDER; BRAIN MONOAMINE-OXIDASE; DOPAMINE TRANSPORTER; GLYCINE TRANSPORTER; RHESUS-MONKEY; WEIGHT-LOSS; OCCUPANCY; C-11;

D O I：

10.1016/j.nbd.2013.08.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The goal of any early central nervous system (CNS) drug development program is always to test the mechanism and not the molecule in order to support additional research investments in late phase clinical trials. Confirmation that drugs reach their targets using translational positron emission tomography (PET) imaging markers of engagement is central to successful clinical proof-of-concept testing and has become an important feature of most neuropsychiatric drug development programs. CNS PET imaging can also play an important role in the clinical investigation of the neuropharmacological basis of psychiatric disease and the optimization of drug therapy. (C) 2013 Published by Elsevier Inc. .

引用

页码：32 / 38

页数：7

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