Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control study

被引：3

作者：

Klerx, Sabrine P. ^{[1
,2
,7
]}

Bruijn, Sjoerd M. ^{[3
]}

Kiers, Henri ^{[1
,2
]}

Coppieters, Michel W. ^{[4
]}

Twisk, Jos W. R. ^{[5
]}

Pool-Goudzwaard, Annelies L. ^{[6
]}

机构：

[1] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Amsterdam Movement Sci, Amsterdam, Netherlands

[2] HU Univ Appl Sci, Sect Movement Adaptat & Prognosis, Res Grp Lifestyle & Hlth, Utrecht, Netherlands

[3] Inst Brain & Behav, Amsterdam, Netherlands

[4] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia

[5] Univ Amsterdam, Dept Epidemiol & Data Sci, Med Ctr, Amsterdam, Netherlands

[6] SOMT Univ Physiotherapy, Amersfoort, Netherlands

[7] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Dept Human Movement Sci, Boechorststr 7, NL-1081 BT Amsterdam, Netherlands

来源：

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS | 2022年 / 30卷

关键词：

Low back pain; Transcranial magnetic stimulation; Cortical organization; Motor control; Sensory tests; MULTIFIDUS MUSCLES; POSTURAL CONTROL; BRAIN; DEFINITIONS; STIMULATION; MOVEMENT; SPINE;

D O I：

10.1016/j.conctc.2022.101022

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: In people with low back pain (LBP), altered motor control has been related to reorganization of the primary motor cortex (M1). Sensory impairments in LBP have also been suggested to be associated with reorganization of M1. Little is known about reorganization of M1 over time in people with LBP, and whether it relates to changes in motor control and sensory impairments and recovery. This study aims to investigate 1) differences in organization of M1 of trunk muscles between people with and without LBP, and whether the organization of M1 relates to motor control and sensory impairments (cross-sectional component) and 2) reorganization of M1 over time and its relation with changes in motor control and sensory impairments and experienced recovery (longitudinal component).Methods: A case-control study with a cross-sectional and five-week longitudinal component is conducted in participants with LBP (N = 25) and participants without LBP (N = 25). Participants with LBP received usual care physiotherapy. Various tests were administered at baseline and follow-up. Following an anatomical MRI, organization of M1 (Center of Gravity and Area of the cortical representation of trunk muscles) was determined using transcranial magnetic stimulation. Quantitative sensory testing, a spiral-tracking motor control test, graphesthesia, two-point discrimination threshold and various self-reported questionnaires were also assessed. Multivariate multilevel analysis will be used for statistical analysis.Conclusion: We will address the gaps in knowledge about the association between reorganization of M1 and motor control and sensory tests during the clinical course of LBP. This study is registered at DOI 10.17605/OSF. IO/5C8ZG.

引用

页数：7