Transaction costs permeate all areas of the country's fisheries sector. Organizations often face similar costs, sometimes without realizing it. The authors consider that, first of all, institutions of interactions of economic entities, public-private partnerships and the integration of business structures should be considered as institutions that determine the institutional framework for regulating transaction costs. The economy of the Kaliningrad region has a fairly high degree of diversification, as evidenced by the structure of the gross regional product. In the region there are no clusters and industries monopolizing the main economic trends of its development. At the same time, the lack of large-scale production and service industries, coupled with increased competition in the Baltic region, sharply limits the opportunities for macro-regional positioning. Exclave nature of the Kaliningrad region and its remoteness from the mainland territory of the Russian Federation by the borders of foreign states creates for it significant competitive problems that hamper development, in comparison with the other regions of the Baltic Sea and the Russian Federation. Returning to the question of determining the institutional framework for regulating transaction costs in the fisheries sector of the region, we rely on the study. The result of the study was a primary analysis of competitive product lines, where a positive role of small business was revealed. As a result, the rationale for choosing a fisheries cluster in the Kaliningrad region was confirmed. (c) 2019 Published by Future Academy www.FutureAcademy.org.UK