Diffuse large B-cell lymphomas, not otherwise specified, and emerging entities

被引：11

作者：

Song, Joo Y. ^{[1
]}

Dirnhofer, Stefan ^{[2
]}

Piris, Miguel A. ^{[3
]}

Quintanilla-Martinez, Leticia ^{[4
,5
,6
]}

Pileri, Stefano ^{[7
]}

Campo, Elias ^{[8
]}

机构：

[1] City Hope Natl Med Ctr, Dept Pathol, 1500 E Duarte Rd, Duarte, CA 91010 USA

[2] Univ Basel, Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland

[3] Fdn Jimenez Diaz, Serv Anat Patol, CIBERONC, Madrid, Spain

[4] Eberhard Karls Univ Tubingen, Inst Pathol & Neuropathol, Tubingen, Germany

[5] Univ Hosp Tubingen, Comprehens Canc Ctr, Tubingen, Germany

[6] Image Guided & Funct Instructed Tumor Therapy, Cluster Excellence iFIT, Tubingen, Germany

[7] European Inst Oncol IRCCS, Div Hematopathol, Milan, Italy

[8] Univ Barcelona, Hosp Clin Barcelona, Inst Biomed Res August Pi I Sunyer IDIBAPS, Hematopathol Unit, Barcelona, Spain

来源：

VIRCHOWS ARCHIV | 2022年 / 482卷 / 1期

关键词：

Diffuse large B-cell lymphoma; Update; Classification; Molecular; Genomics; CENTRAL-NERVOUS-SYSTEM; PREVIOUSLY UNTREATED PATIENTS; EFFUSION-BASED LYMPHOMA; EXPRESSION PREDICTS; CD79B MUTATIONS; GENE-EXPRESSION; MYD88; L265P; R-CHOP; CLASSIFICATION; MYC;

D O I：

10.1007/s00428-022-03466-6

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogenous group of diseases and the most common subtype of non-Hodgkin lymphoma. In the past decade, there has been an explosion in molecular profiling that has helped to identify subgroups and shared oncogenic driving mechanisms. Since the 2017 World Health Organization (WHO) classification, additional studies investigating these genomic abnormalities and phenotypic findings have been reported. Here we review these findings in DLBCL and address the proposed changes by the 2022 International Consensus Classification.

引用

页码：179 / 192

页数：14

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