Ligand-Enabled Alkynylation of C(sp3)-H Bonds with Palladium(II) Catalysts

被引：43
|
作者：
Fu, Haiyan [1 ]
Shen, Peng-Xiang [1 ]
He, Jian [1 ]
Zhang, Fanglin [1 ]
Li, Suhua [1 ]
Wang, Peng [1 ]
Liu, Tao [1 ]
Yu, Jin-Quan [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 07期
关键词：
alkynylation; amino acids; C-H activation; palladium; pyridine; C-H ALKYNYLATION; ALPHA-AMINO-ACIDS; ROOM-TEMPERATURE; TERMINAL ALKYNES; CHELATION-ASSISTANCE; C(SP(2))-H BONDS; DIRECTING GROUP; MILD CONDITIONS; DERIVATIVES; ACTIVATION;
D O I：
10.1002/anie.201610426
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The palladium(II)-catalyzed beta-and-alkynylation of amide C(sp(3))-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing alpha-tertiary or alpha-quaternary carbon centers. The beta-methylene C(sp(3))-H bonds of various carbocyclic rings were also successfully alkynylated.
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页码：1873 / 1876
页数：4
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