Novel small molecule activators of β-catenin-mediated signaling pathway: structure-activity relationships of indirubins

被引：12

作者：

Park, Eun-Jung ^{[1
]}

Choi, Soo Jeong ^{[2
]}

Kim, Yong-Chul ^{[2
]}

Lee, Sang Hyung ^{[3
]}

Park, Seoung Woo ^{[4
]}

Lee, Sang Kook ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

[2] Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea

[3] Seoul Natl Univ, Coll Med, Seoul 156707, South Korea

[4] Kangwon Natl Univ, Sch Med, Chunchon 200947, Gangwon, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 08期

关键词：

Wnt signaling; Novel activator of Wnt signaling; Indirubin; 5-Nitro-3 '-monoxime; beta-Catenin; WNT; KINASE; DERIVATIVES; INHIBITORS; ADHESION;

D O I：

10.1016/j.bmcl.2009.02.083

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on the beta-catenin-drived Wnt activator of bromoindirubin-3'-oxime (BIO), indirubin analogs were evaluated for beta-catenin-mediated gene expression. A novel indirubin analog, indirubin-5-nitro-3'-oxime (INO), was considered a potential activator, and structure-activity studies were conducted with indirubins. These data suggest that INO might be a novel Wnt activator and has a potential of signaling regulator in beta-catenin-mediated signaling pathways. (c) 2009 Elsevier Ltd. All rights reserved.

引用

下载

页码：2282 / 2284

页数：3

共 50 条

[21] Investigation of Structure-Activity Relationships for Small-Molecule Inhibitors of Human DNA Polymerase Eta
Zafar, Maroof K.
Maddukuri, Leena
Eddy, Sarah
Ketkar, Amit
Penthala, Narsima R.
Crooks, Peter A.
Eoff, Robert L.
FASEB JOURNAL, 2016, 30
[22] Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors
Dumas, J
Brittelli, D
Chen, JS
Dixon, B
Hatoum-Mokdad, H
König, G
Sibley, R
Witowsky, J
Wong, S
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (17) : 2531 - 2536
[23] Hologram quantitative structure-activity relationships for a series of farnesoid X receptor activators
Honorio, KM
Garratt, RC
Andricopulo, AD
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (12) : 3119 - 3125
[24] Evolution of the insulin molecule: insights into structure-activity and phylogenetic relationships
Conlon, JM
PEPTIDES, 2001, 22 (07) : 1183 - 1193
[25] Activators of P-glycoprotein: Structure-Activity Relationships and Investigation of their Mode of Action
Sterz, Katja
Moellmann, Lars
Jacobs, Anna
Baumert, Dieter
Wiese, Michael
CHEMMEDCHEM, 2009, 4 (11) : 1897 - 1911
[26] Identification and Characterization of a Novel Small-Molecule Inhibitor of β-Catenin Signaling
Delgado, Evan R.
Yang, Jing
So, Juhoon
Leimgruber, Stephanie
Kahn, Michael
Ishitani, Tohru
Shin, Donghun
Wilson, Gabriela Mustata
Monga, Satdarshan P.
AMERICAN JOURNAL OF PATHOLOGY, 2014, 184 (07): : 2111 - 2122
[27] MEDI 92-Discovery of novel small molecule activators of NFkB pathway
Gong, Gangli
Xie, Yuli
Liu, Yidong
Rinderspacher, Alison
Deng, Shi-Xian
Landry, Donald W.
Wyler, Michael
Aulner, Nathalie
Toebben, Udo
Smith, Deborah H.
Branden, Lars
Chung, Caty
Schuerer, Stephan
Vidovic, Dusica
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
[28] Antimicrobial agent chloroxylenol targets β-catenin-mediated Wnt signaling and exerts anticancer activity in colorectal cancer
Sun, Qi
Liu, Boxin
Lan, Quanxue
Su, Zijie
Fu, Qiuxia
Wang, Lian
Deng, Yingying
Li, Chuanli
Xue, Vivian Weiwen
Liu, Shanshan
Chen, Xianxiong
Yang, Guowu
Lu, Desheng
INTERNATIONAL JOURNAL OF ONCOLOGY, 2023, 63 (05)
[29] Structure-activity relationships and pathway analysis of biological degradation processes
Kadowaki, Tadashi
Wheelock, Craig E.
Hattori, Masahiro
Goto, Susumu
Kanehisa, Minoru
JOURNAL OF PESTICIDE SCIENCE, 2006, 31 (03) : 273 - 281
[30] Synthesis and structure-activity relationships of novel neocryptolepine derivatives
Ahmed A. El-Gokha
Nader M. Boshta
Mona K. Abo Hussein
Ibrahim El-T. El Sayed
Chemical Research in Chinese Universities, 2017, 33 : 373 - 377

← 1 2 3 4 5 →