Novel small molecule activators of β-catenin-mediated signaling pathway: structure-activity relationships of indirubins

被引：12
|
作者：
Park, Eun-Jung [1 ]
Choi, Soo Jeong [2 ]
Kim, Yong-Chul [2 ]
Lee, Sang Hyung [3 ]
Park, Seoung Woo [4 ]
Lee, Sang Kook [1 ]
机构：
[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
[2] Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea
[3] Seoul Natl Univ, Coll Med, Seoul 156707, South Korea
[4] Kangwon Natl Univ, Sch Med, Chunchon 200947, Gangwon, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 08期
关键词：
Wnt signaling; Novel activator of Wnt signaling; Indirubin; 5-Nitro-3 '-monoxime; beta-Catenin; WNT; KINASE; DERIVATIVES; INHIBITORS; ADHESION;
D O I：
10.1016/j.bmcl.2009.02.083
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Based on the beta-catenin-drived Wnt activator of bromoindirubin-3'-oxime (BIO), indirubin analogs were evaluated for beta-catenin-mediated gene expression. A novel indirubin analog, indirubin-5-nitro-3'-oxime (INO), was considered a potential activator, and structure-activity studies were conducted with indirubins. These data suggest that INO might be a novel Wnt activator and has a potential of signaling regulator in beta-catenin-mediated signaling pathways. (c) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2282 / 2284
页数：3
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