Current applications of poly(lactic acid) composites in tissue engineering and drug delivery

被引：330
|
作者：
Liu, Shan [1 ,2 ]
Qin, Shuhao [3 ,4 ]
He, Min [3 ,4 ]
Zhou, Dengfeng [1 ,2 ]
Qin, Qingdong [1 ,2 ]
Wang, Hao [5 ]
机构：
[1] Guizhou Inst Technol, Coll Mat & Energy Engn, Guiyang 550003, Peoples R China
[2] Guizhou Inst Technol, Key Lab Light Met Mat Proc Technol Guizhou Prov, Guiyang 550003, Peoples R China
[3] Natl Engn Res Ctr Compounding & Modificat Polymer, Guiyang 550014, Peoples R China
[4] Guizhou Univ, Coll Mat & Met, Dept Polymer Mat & Engn, Guiyang 550025, Peoples R China
[5] Univ Southern Queensland, Ctr Future Mat, Toowoomba, Qld 4350, Australia
来源：
COMPOSITES PART B-ENGINEERING | 2020年 / 199卷
关键词：
Poly(lactic acid); Biocomposite; Tissue engineering; Drug delivery; Fabrication; Scaffold; POLY LACTIC-ACID; INDUCED PHASE-SEPARATION; IN-VITRO; FLAME RETARDANCY; CELLULOSE NANOCRYSTALS; MECHANICAL-PROPERTIES; GRAPHENE NANOSHEETS; POROUS SCAFFOLDS; HYDROXYAPATITE COMPOSITE; RHEOLOGICAL PROPERTIES;
D O I：
10.1016/j.compositesb.2020.108238
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Biodegradable poly(lactic acid) (PLA) presents suitable physicochemical properties and biocompatibility for biomedical engineering. However, PLA has some drawbacks, such as low cell adhesion, biological inertness, low degradation rate, and acid degradation by-products. In this review, recent progress on strategies to address these problems is summarized, including novel fabrication techniques, high-performance PLA composites, and their applications for tissue engineering and drug delivery. The scaffolds, especially for bone regeneration, blood vessels, organs, and skin regeneration are evaluated, in terms of in vivo and in vitro biocompatibility and biodegradability. The enhanced mechanical, thermal, and rheological properties of PLA biocomposites are analyzed in detail. PLA biocomposites for drug encapsulation, sustained release, and tumor-targeting are also reviewed. Furthermore, the challenges and future perspectives on PLA-based biocomposites are discussed.
引用
收藏
页数：25
相关论文
共 50 条
  • [11] Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances
    Vlachopoulos, Antonios
    Karlioti, Georgia
    Balla, Evangelia
    Daniilidis, Vasileios
    Kalamas, Theocharis
    Stefanidou, Myrika
    Bikiaris, Nikolaos D.
    Christodoulou, Evi
    Koumentakou, Ioanna
    Karavas, Evangelos
    Bikiaris, Dimitrios N.
    PHARMACEUTICS, 2022, 14 (02)
  • [12] Chemical enhancements and advanced manufacturing methods of Poly (Lactic acid) for tissue engineering applications
    Fredericks, Cole Martin
    Kunihiro, Joshua K. I.
    Zheng, Hanjia
    Waghu, Naweed Rizwan
    Kamkar, Milad
    POLYMER, 2024, 313
  • [13] Review: Syntheses of poly(lactic acid)s and their block copolymers for drug delivery applications
    Oktavia, Linda W.
    Begue, Didier
    Campana, Patricia Targon
    Hiorns, Roger C.
    POLYMER INTERNATIONAL, 2023, 72 (10) : 881 - 898
  • [14] A Poly(Lactic Acid-Co-Caprolactone)-Collagen Hybrid for Tissue Engineering Applications
    Ananta, M.
    Aulin, Cecilia E.
    Hilborn, Joens
    Aibibu, Dilibaier
    Houis, Stephanie
    Brown, Robert A.
    Mudera, Vivek
    TISSUE ENGINEERING PART A, 2009, 15 (07) : 1667 - 1675
  • [15] A poly-L-lactic acid/ collagen/glycosaminoglycan matrix for tissue engineering applications
    Pavia, F. Carfi
    Ciappa, M.
    Lepedda, A.
    Fiorentino, S. M.
    Rigogliuso, S.
    Brucato, V.
    Formato, M.
    Ghersi, G.
    La Carrubba, V.
    JOURNAL OF CELLULAR PLASTICS, 2017, 53 (05) : 537 - 549
  • [16] Development of poly (mannitol sebacate)/poly (lactic acid) nanofibrous scaffolds with potential applications in tissue engineering
    Rahmani, Mahya
    Khani, Mohammad-Mehdi
    Rabbani, Shahram
    Mashaghi, Alireza
    Noorizadeh, Farsad
    Faridi-Majidi, Reza
    Ghanbari, Hossein
    MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 110 (110):
  • [17] Epoxy-poly lactic acid blended composites reinforced with carbon fibres for engineering applications
    Revankar, Suraj
    Banapurmath, N. R.
    Sajjan, Ashok M.
    Nimbagal, Vijayakumar
    Patil, Arun Y.
    Venkatesh, R.
    Umarfarooq, M. A.
    Vadlamudi, Chandramouli
    Krishnappa, Sanjay
    MATERIALS EXPRESS, 2022, 12 (12) : 1502 - 1511
  • [18] Poly(organo)phosphazenes: recent progress in the synthesis and applications in tissue engineering and drug delivery
    Khan, Rizwan Ullah
    Wang, Li
    Yu, Haojie
    Zain-ul-Abdin
    Akram, Muhammad
    Wu, Jialiang
    Haroon, Muhammad
    Ullah, Raja Summe
    Deng, Zheng
    Xia, Xia
    RUSSIAN CHEMICAL REVIEWS, 2018, 87 (02) : 109 - 150
  • [19] POLY 345-Nanostructured hybrid hydrogels for tissue engineering and drug delivery applications
    Bencherif, Sidi A.
    Siegwart, Daniel J.
    Srinivasan, Abiraman
    Hollinger, Jeffrey O.
    Washburn, Newell R.
    Matyjaszewski, Krzysztof
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
  • [20] Engineering of Bioresorbable Polymers for Tissue Engineering and Drug Delivery Applications
    Dobrzynska-Mizera, Monika
    Dodda, Jagan Mohan
    Liu, Xiaohua
    Knitter, Monika
    Oosterbeek, Reece N.
    Salinas, Pablo
    Pozo, Eduardo
    Ferreira, Ana Marina
    Sadiku, Emmanuel Rotimi
    ADVANCED HEALTHCARE MATERIALS, 2024, 13 (30)
12345