An unusual dimeric structure of a Cu(I) bis(thiosemicarbazone) complex: Implications for the mechanism of hypoxic selectivity of the Cu(II) derivatives

被引：170

作者：

Cowley, AR

Dilworth, JR

Donnelly, PS

Labisbal, E

Sousa, A

机构：

[1] Univ Oxford, Inorgan Chem Lab, Oxford OX1 3QR, England

[2] Univ Santiago de Compostela, Dept Quim Inorgan, Santiago De Compostela 15706, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 19期

关键词：

D O I：

10.1021/ja012668z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The electrochemical reduction of Cu(II) bis(thiosemicarbazone) complexes [Cu(II)(btsc)] is accompanied by protonation to give an unstable Cu(I) intermediate [Cu(btscH2)]+. The nature of this intermediate was probed by reaction of bis(thiosemicarbazone) ligands with a Cu(I) precursor which gave a novel helical dimeric dicationic complex. The dependence of these reactions on the ligand backbone substituents is discussed together with their possible relevance to the use of Cu(II) bis(thiosemicarbazone) ligands as hypoxic selective imaging and therapeutic agents. Copyright © 2002 American Chemical Society.

引用

页码：5270 / 5271

页数：2

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