Development of New LC Chiral Stationary Phases Based on Ruthenium Tris(diimine) Complexes

被引：3

作者：

Sun, P. ^{[1
]}

Perera, S. ^{[1
]}

MacDonnell, F. M. ^{[1
]}

Armstrong, D. W. ^{[1
]}

机构：

[1] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2009年 / 32卷 / 14期

关键词：

Binding chemistry; Chiral stationary phase; Enantioresolution; Ru tris(diimine) complex; CLAY COLUMN CHROMATOGRAPHY; PERFORMANCE LIQUID-CHROMATOGRAPHY; CYCLODEXTRIN-BONDED PHASES; OPTICAL RESOLUTION; MONTMORILLONITE COLUMN; SEPARATION; ENANTIOMERS; HPLC; CELLULOSE; ADDUCT;

D O I：

10.1080/10826070903126781

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Enantiopure ruthenium(II) tris(diimine) complexes have been covalently bonded to silica and evaluated as chiral stationary phases for LC. Three binding chemistries were tested and the CSP synthesized by reductive amination of the aldehyde-functionalized silica provided the largest enantioselectivity. The Ru complex bonded CSP showed selectivity toward a variety of racemic compounds. Circular dichroism (CD) detection was used to confirm the enantiomeric separations. This CSP worked especially well for the enantiomeric separation of binaphthyl type compounds in the normal phase mode and appeared to be selective for acidic compounds in the polar organic mode. Effects of mobile phase composition on the enantioseparations were also studied.

引用

页码：1979 / 2000

页数：22

共 50 条

[11] Enantiomeric Separations of Ruthenium (II) Polypyridyl Complexes Using HPLC With Cyclofructan Chiral Stationary Phases
Shu, Yang
Breitbach, Zachary S.
Dissanayake, Milan K.
Perera, Sirantha
Aslan, Joseph M.
Alatrash, Nagham
MacDonnell, Frederick M.
Armstrong, Daniel W.
CHIRALITY, 2015, 27 (01) : 64 - 70
[12] Tris(phenylcarbamate) derivative of amylopectin as chiral stationary phases in HPLC
Chassaing, C.
Thienpont, M.-H.S.A.
Felix, G.
Journal of High Resolution Chromatography, 1995, 18 (06):
[13] Preparation and enantioseparation property of chiral stationary phases based on cellulose tris(3,5-dimethylbenzoate) - A new way to prepare polysaccharide-coating type chiral stationary phases
Chen, Wei
Duan, Rong
Fan, Qing-chun
Bai, Zheng-wu
Huang, Shao-hua
CHINESE JOURNAL OF POLYMER SCIENCE, 2014, 32 (04) : 458 - 466
[14] Preparation and enantioseparation property of chiral stationary phases based on cellulose tris(3,5-dimethylbenzoate) — A new way to prepare polysaccharide-coating type chiral stationary phases
Wei Chen
Rong Duan
Qing-chun Fan
Zheng-wu Bai
Shao-hua Huang
Chinese Journal of Polymer Science, 2014, 32 : 458 - 466
[15] TRIS(PHENYLCARBAMATE) DERIVATIVES OF AMYLOPECTIN AS CHIRAL STATIONARY PHASES IN HPLC
CHASSAING, C
THIENPONT, MHSA
FELIX, G
HRC-JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY, 1995, 18 (06): : 389 - 391
[16] Preparation and Enantioseparation Property of Chiral Stationary Phases Based on Cellulose Tris(3,5-dimethylbenzoate)——A New Way to Prepare Polysaccharide-coating Type Chiral Stationary Phases
Wei Chen
Rong Duan
Qing-chun Fan
柏正武
黄少华
Chinese Journal of Polymer Science, 2014, 32 (04) : 458 - 466
[17] CHIRAL STATIONARY PHASES FOR LC AND SFC OBTAINED BY POLYMER COATING
RUFFING, FJ
LUX, JA
ROEDER, W
SCHOMBURG, G
CHROMATOGRAPHIA, 1988, 26 : 19 - 28
[18] Role of the carbohydrate moieties in chiral recognition on teicoplanin-based LC stationary phases
Berthod, A
Chen, XH
Kullman, JP
Armstrong, DW
Gasparrini, F
D'Acquarica, I
Villani, C
Carotti, A
ANALYTICAL CHEMISTRY, 2000, 72 (08) : 1767 - 1780
[19] The use of cyclodextrin-based LC stationary phases for the separation of chiral dihydrobenzofuran derivatives
Soukup, RJ
Rozhkov, RV
Larock, RC
Armstrong, DW
CHROMATOGRAPHIA, 2005, 61 (5-6) : 219 - 224
[20] The Use of Cyclodextrin-Based LC Stationary Phases for the Separation of Chiral Dihydrobenzofuran Derivatives
R. J. Soukup
R. V. Rozhkov
R. C. Larock
D. W. Armstrong
Chromatographia, 2005, 61 : 219 - 224

← 1 2 3 4 5 →