Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity

被引:58
|
作者
Pippa, R. [1 ]
Dominguez, A. [1 ]
Christensen, D. J. [2 ]
Moreno-Miralles, I. [1 ]
Blanco-Prieto, M. J. [3 ]
Vitek, M. P. [2 ]
Odero, M. D. [1 ,4 ]
机构
[1] Univ Navarra, Ctr Appl Med Res CIMA, Hematol Oncol Program, Navarra, Spain
[2] Oncotide Pharmaceut, Res Triangle Pk, NC USA
[3] Univ Navarra, Sch Pharm, Dept Pharm & Pharmaceut Technol, Navarra, Spain
[4] Univ Navarra, Dept Biochem & Genet, Navarra, Spain
关键词
PROTEIN PHOSPHATASE 2A; INHIBITION; I-2(PP2A)/SET; ACTIVATION; EFFICACY; THERAPY; EVENT;
D O I
10.1038/leu.2014.141
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1915 / 1918
页数:4
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