Diterpenoids from Isodon enanderianus

被引：12
|
作者：
Na, Z [1 ]
Xiang, W [1 ]
Niu, XM [1 ]
Mei, SX [1 ]
Lin, ZW [1 ]
Li, CM [1 ]
Sun, HD [1 ]
机构：
[1] Acad Sinica, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
来源：
PHYTOCHEMISTRY | 2002年 / 60卷 / 01期
关键词：
Isodon enanderianus; labiatae; ent-kaurane diterpenoids; 6-epiangustifolin; enanderinanin F-H;
D O I：
10.1016/S0031-9422(02)00073-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four ent-kauranoids, 6-epiangustifolin and enanderinanins F H, as well as 11 known ent-kaurane diterpenoids, macrocalin B, xerophilusin A, trichorabdal A, trichorabdal B, effusin, angustifolin, longikaurin D, longikaurin F, enanderinanin B, xerophilusin G and shikokianin were isolated from the aerial parts of Isodon enanderianus. The new diterpenoids were identified as 6-epiangustifolin (11alpha-hydroxy-6alpha-methoxy-6,19-epoxy-6,7-seco-ent-kaur-16-en-15-one-7,20-olide), enanderinanin F (19-acetoxy-6,20:6,11beta-diepoxy-6,7-seco-ent-kaur-16-en-15-one-1beta,7-olide), enanderinanin G (1beta,6beta,7beta-trihydroxy-19-acetoxy-16beta-methoxymethyl-7alpha,20-epoxy-ent-kaur-15-one) and enanderinanin H (6beta,7beta,14beta-trihydroxy-1alpha,11beta-acetonide-7alpha,20-epoxy-ent-kaur-16-en-15-one), respectively, on the basis of spectral data, especially by 2D NMR techniques. 6-Epiangustifolin showed significant cytotoxic activity against K562 cell. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：55 / 60
页数：6
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