Psychiatric and Psychological Aspects in the Ehlers-Danlos Syndromes

被引:86
|
作者
Bulbena, Antonio [1 ]
Baeza-Velasco, Carolina [2 ]
Bulbena-Cabre, Andrea [3 ]
Pailhez, Guillem [1 ]
Critchley, Hugo [4 ]
Chopra, Pradeep [5 ]
Mallorqui-Bague, Nuria [6 ]
Frank, Charissa [7 ]
Porges, Stephen [8 ]
机构
[1] Autonoma Univ Barcelona, Dept Psychiat, Barcelona, Spain
[2] Paris Descartes Univ, Clin Psychol, Paris, France
[3] JJ Peters Bronx VA Hosp, Icahn Sch Med Mt Sinai, Bronx, NY USA
[4] Univ Sussex, Psychiat Dept, Brighton, E Sussex, England
[5] Brown Univ, Warren Alpert Med Sch, Med, Providence, RI 02912 USA
[6] Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain
[7] Flemish Patient Org Hereditary Collagen Disorders, Ghent, Belgium
[8] Univ N Carolina, Psychiat, Chapel Hill, NC USA
关键词
joint hypermobility; anxiety; psychopathology; neuroconnective phenotype; hypermobile Ehlers-Danlos syndrome; JOINT HYPERMOBILITY SYNDROME; DEVELOPMENTAL COORDINATION DISORDER; ANXIETY DISORDERS; SOMATIC SYMPTOMS; PANIC DISORDER; PAIN; ASSOCIATION; WOMEN; BODY; QUESTIONNAIRE;
D O I
10.1002/ajmg.c.31544
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
There is increasing amount of evidence pointing toward a high prevalence of psychiatric conditions among individuals with hypermobile type of Ehlers-Danlos syndrome (JHS/hEDS). A literature review confirms a strong association between anxiety disorders and JHSh/hEDS, and there is also limited but growing evidence that JHSh/hEDS is also associated with depression, eating, and neuro-developmental disorders as well as alcohol and tobacco misuse. The underlying mechanisms behind this association include genetic risks, autonomic nervous system dysfunction, increased exteroceptive and interoceptive mechanisms and decreased proprioception. Recent neuroimaging studies have also shown an increase response in emotion processing brain areas which could explain the high affective reactivity seen in JHS/hEDS. Management of these patients should include psychiatric and psychological approaches, not only to relieve the clinical conditions but also to improve abilities to cope through proper drug treatment, psychotherapy, and psychological rehabilitation adequately coupled with modern physiotherapy. A multidimensional approach to this "neuroconnective phenotype" should be implemented to ensure proper assessment and to guide for more specific treatments. Future lines of research should further explore the full dimension of the psychopathology associated with JHS/hEDS to define the nature of the relationship. (C) 2017 Wiley Periodicals, Inc.
引用
收藏
页码:237 / 245
页数:9
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