Synthesis of diethyl 4-(phenyl-substituted)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates catalyzed by CoCl2/K-10 montmorillonite in water and their antimicrobial activity

被引：8
|
作者：
Bajaj, S. D. [1 ]
Mahodaya, O. A. [1 ]
Tekade, P. V. [1 ]
Patil, V. B. [1 ]
Kukade, Suraj D. [1 ]
机构：
[1] Jankidevi Bajaj Coll Sci, Dept Chem, Civil Lines, Jamnalal Bajaj Marg, Wardha 442001, India
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2017年 / 87卷 / 03期
关键词：
antimicrobial activity; CoCl2; catalyst; 1,4-dihydropyridine; Hantszch reaction; K-10; montmorillonite; 1,4-DIHYDROPYRIDINES; DERIVATIVES;
D O I：
10.1134/S1070363217030264
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and efficient method of one pot synthesis of 1,4-dihydropyridine by three components reaction of aromatic aldehydes with 1,3-dicarbonyl compound, ammonium acetate and catalytic amount of CoCl2 based on the Hantszch reaction is developed. The process is catalysis by an inexpensive catalyst in water medium, gives high yield of products and involves no volatile organic solvents. Some synthesized compounds demonstrated antimicrobial activity.
引用
收藏
页码：546 / 549
页数：4
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