Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: A randomized clinical trial

被引:10
|
作者
Jung, Minyoung [1 ,2 ]
Lee, Ji Young [3 ]
Ryu, Gwanghui [4 ]
Lee, Kyung Eun [4 ]
Hong, Sang Duk [4 ]
Choi, Jaehee [5 ]
Kim, Soyoung [2 ]
Ahn, Kangmo [2 ,6 ]
Dhong, Hun-Jong [4 ]
Chung, Seung-Kyu [4 ]
Kim, Jihyun [2 ,6 ]
Kim, Hyo Yeol [4 ]
机构
[1] Kosin Univ, Coll Med, Kosin Univ Gospel Hosp, Dept Pediat, Busan, South Korea
[2] Samsung Med Ctr, Environm Hlth Ctr Atop Dis, Seoul, South Korea
[3] Hallym Univ, Hangang Sacred Heart Hosp, Dept Pediat, Chunchon, South Korea
[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, 81 Irwon Ro, Seoul 06351, South Korea
[5] Sahmyook Med Ctr, Dept Pediat, Seoul, South Korea
[6] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, 81 Irwon Ro, Seoul 06351, South Korea
来源
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY | 2020年 / 38卷 / 04期
关键词
hypersensitivity; obstructive lung disease; asthma; allergic rhinitis; allergic disease; symptom score; HYPERTONIC SALINE; IMPACT; EFFICACY; NOSE;
D O I
10.12932/AP-070918-0403
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Asthma and allergic rhinitis (AR) are chronic inflammatory diseases of airway and affect the disease severity each other. Objective: We performed this study to examine whether nasal saline irrigation (NSI) improves bronchial hyperresponsiveness and clinical parameters in children with asthma and allergic rhinitis (AR). Methods: We enrolled 20 children with AR and asthma aged between 6-18 years. Patients were randomized into two groups: irrigation group (8 boys and 2 girls) and control group (8 boys and 2 girls). The irrigation group performed daily NSI. All patients received 12-week treatment with montelukast, levocetirizine, and inhaled glucocorticoids. Provocative concentrations of methacholine causing a 20% decrease in FEV1 (PC20), Asthma Control Test (ACT), the Questionnaire for Quality-of-Life Specific to Allergic Rhinitis in Korean Children (QQOL-ARK) and exhaled nitric oxide (FENO) were compared before and after the study. Results: The PC20 at week 12 was higher than baseline measurements in the irrigation group (P = 0.017), while there was no difference in PC20 before and after treatment in the control group (P = 0.333). ACT score increased after 12 weeks of NSI (P = 0.007), while QQOL-ARK score decreased compared to baseline scores (P = 0.028) in the irrigation group. No differences in ACT and QQOL-ARK were found between weeks 0 and 12 in the control group. No differences were found in the median value of changes in PC20, ACT, QQOL-ARK and FENO between the irrigation and control groups. Conclusions: Our results suggest that NSI is beneficial for treatment of asthma and AR in children.
引用
收藏
页码:251 / 257
页数:7
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