Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine

被引：8

作者：

Keglevich, Andras ^{[1
]}

Szigetvari, Aron ^{[2
]}

Dekany, Miklos ^{[2
]}

Szantay, Csaba, Jr. ^{[2
]}

Keglevich, Peter ^{[1
]}

Hazai, Laszlo ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, Gellert Ter 4, H-1111 Budapest, Hungary

[2] Gedeon Richter Plc, Spectroscop Res Dept, 10,POB 27, H-1475 Budapest, Hungary

来源：

CURRENT ORGANIC CHEMISTRY | 2019年 / 23卷 / 07期

基金：

匈牙利科学研究基金会;

关键词：

Anticancer drugs; dimer Vinca alkaloids; vindoline; triphenylphosphine; phosphonium salts; antiproliferative activity; HYBRID MOLECULES; VINORELBINE; MICROTUBULES; FEASIBILITY; VINBLASTINE; INHIBITORS; ALKALOIDS; INSIGHTS; DESIGN;

D O I：

10.2174/1385272823666190524083236

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives were coupled with triphenylphosphine, to afford the expected phosphonium salts. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated.

引用

页码：852 / 858

页数：7

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