Modulation of Respiratory Function by 5,10,15,20-Tetrakis(N-methyl-4-pyridyl)Porphyrin-Zn(II) Tetrachloride in Isolated Rat Liver Mitochondria

被引：0

作者：

Kerti, Viorica ^{[1
]}

Coricovac, Dorina ^{[2
]}

Duicu, Oana ^{[1
]}

Danila, Maria ^{[1
]}

Dehelean, Cristina ^{[2
]}

Fagadar-Cosma, Eugenia ^{[3
]}

Muntean, Danina ^{[1
]}

Noveanu, Lavinia ^{[1
]}

机构：

[1] Victor Babes Univ Med & Pharm, Fac Med, Dept Pathophysiol, Timisoara 300041, Romania

[2] Victor Babes Univ Med & Pharm, Fac Pharm, Dept Toxicol, Timisoara 300041, Romania

[3] Romanian Acad, Inst Chem Timisoara, Timisoara 300223, Romania

来源：

REVISTA DE CHIMIE | 2014年 / 65卷 / 04期

关键词：

Zn-metalloporphyrin; rat liver mitochondria; respiratory parameters; uncoupling; ZINC PROTOPORPHYRIN;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mitochondria plays the central role in several degenerative and hyperproliferative pathologies and characterization of compounds able to enter mitochondria represents a highly targeted field for drug development. In the present paper we investigated the effects of a water-soluble porphyrin, 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin-Zn(II)-tetrachloride (Zn-TNMPyP) on parameters of respiratory function in isolated rat liver mitochondria. Our data show that Zn-TNMPyP acts as a potent uncoupler of mitochondria with potential therapeutic effect.

引用

页码：447 / 449

页数：3

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