Modulation of Respiratory Function by 5,10,15,20-Tetrakis(N-methyl-4-pyridyl)Porphyrin-Zn(II) Tetrachloride in Isolated Rat Liver Mitochondria

被引：0
|
作者：
Kerti, Viorica [1 ]
Coricovac, Dorina [2 ]
Duicu, Oana [1 ]
Danila, Maria [1 ]
Dehelean, Cristina [2 ]
Fagadar-Cosma, Eugenia [3 ]
Muntean, Danina [1 ]
Noveanu, Lavinia [1 ]
机构：
[1] Victor Babes Univ Med & Pharm, Fac Med, Dept Pathophysiol, Timisoara 300041, Romania
[2] Victor Babes Univ Med & Pharm, Fac Pharm, Dept Toxicol, Timisoara 300041, Romania
[3] Romanian Acad, Inst Chem Timisoara, Timisoara 300223, Romania
来源：
REVISTA DE CHIMIE | 2014年 / 65卷 / 04期
关键词：
Zn-metalloporphyrin; rat liver mitochondria; respiratory parameters; uncoupling; ZINC PROTOPORPHYRIN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mitochondria plays the central role in several degenerative and hyperproliferative pathologies and characterization of compounds able to enter mitochondria represents a highly targeted field for drug development. In the present paper we investigated the effects of a water-soluble porphyrin, 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin-Zn(II)-tetrachloride (Zn-TNMPyP) on parameters of respiratory function in isolated rat liver mitochondria. Our data show that Zn-TNMPyP acts as a potent uncoupler of mitochondria with potential therapeutic effect.
引用
收藏
页码：447 / 449
页数：3
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