Artificial Ribozyme Switches Containing Natural Riboswitch Aptamer Domains

被引：98
|
作者：
Wieland, Markus [1 ,2 ]
Benz, Armin [1 ,2 ]
Klauser, Benedikt [1 ,2 ]
Hartig, Joerg S. [1 ,2 ]
机构：
[1] Univ Konstanz, Dept Chem, D-78457 Constance, Germany
[2] Univ Konstanz, KoRS CB, D-78457 Constance, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 15期
关键词：
riboswitches; ribozymes; RNA structures; synthetic biology; thiamine; BACTERIAL GENE-EXPRESSION; SENSING RIBOSWITCH; SYNTHETIC BIOLOGY; SMALL MOLECULES; MESSENGER-RNAS; IN-VIVO; LIGAND; PYROPHOSPHATE; BINDING; TRANSCRIPTION;
D O I：
10.1002/anie.200805311
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
RNA Lego: The use of natural riboswitch aptamers in synthetic RNA switches (see picture) should broaden the scope of artificial RNA regulators dramatically. It is shown that thiamine pyrophosphate (TPP) aptamers can be used in engineered devices as very sensitive switches of gene expression in unmodified organisms. The approach demonstrates that intrinsic metabolites can be utilized as external effectors of cellular functions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2715 / 2718
页数：4
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