Terpenoids from Melampodium perfoliatum

被引：6

作者：

Arciniegas, Amira ^{[1
]}

Perez-Castorena, Ana-L. ^{[1
]}

Nieto-Camacho, Antonio ^{[1
]}

Villasenor, Jose L. ^{[2
]}

de Vivar, Alfonso Romo ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Inst Biol, Ciudad Univ, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 11期

关键词：

SESQUITERPENE LACTONES; DITERPENE LACTONES; SMALLANTHUS-SONCHIFOLIUS; MELAMPOLIDES; MACROPHAGES; DERIVATIVES; INHIBITION; LEUCANTHUM; LEAVES;

D O I：

10.1021/acs.jnatprod.6b00321

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The phytochemical study of the aerial parts of Melampodium perfoliatum afforded six melampolides (1, 3, 5-8), a eudesmanolide (9), two diterpene lactones (10, 11), and two entkaurane derivatives (12, 13), together with the known melampodin (2) and polymatin A (4). The structures of the compounds were elucidated by physical data analysis and chemical reactions. Compounds 2, 4, 5, and 10 exhibited dose-dependent anti-inflammatory activity on the 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model, with ID50 values of 1.14, 0.56, 1.15, and 1.49 mu mol/ear, respectively, compared to the reference compound indomethacin (0.24 mu mol/ear).

引用

页码：2780 / 2787

页数：8

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