The Semi-synthesis and Cytotoxic Activity of Trametenolic acid B Derivatives

被引：0
|
作者：
Zhang, Qiaoyin [1 ]
Ding, Mingruo [1 ]
Zhai, Weichen [1 ]
Yao, Yuan [1 ]
Zhou, Yanmei [1 ]
Wang, Junzhi [1 ]
机构：
[1] China Three Gorges Univ, Coll Chem & Life Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Hubei, Peoples R China
来源：
ADVANCES IN CHEMICAL ENGINEERING III, PTS 1-4 | 2013年 / 781-784卷
关键词：
Triterpenoid; trametenolic acid B; cytotoxic activity; semi-synthesis; breast cancer MDA-MB-231 cells;
D O I：
10.4028/www.scientific.net/AMR.781-784.1126
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The trametenolic acid B was a bioactive lanostane-type triterpenoid in Trametes lactinea (Berk.) Pat with. Five novel trametenolic acid B derivatives were synthesized, characterized and evaluated the cytotoxicity against MDA-MB-231 cells with the aim of obtaining better anti-tumtor agents. The compound IV exhibited significantly cytotoxicity activities with IC50 value of 22.39 mu M.
引用
收藏
页码：1126 / 1129
页数：4
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