Synthesis of oxindole from acetanilide via Ir(III)-catalyzed C-H carbenoid functionalization

被引：54

作者：

Patel, Pitambar ^{[1
]}

Borah, Gongutri ^{[1
]}

机构：

[1] CSIR North East Inst Sci & Technol, Chem Sci & Technol Div, Jorhat 785006, Assam, India

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 02期

关键词：

METAL-FREE SYNTHESIS; INTRAMOLECULAR ALPHA-ARYLATION; DIAZO-COMPOUNDS; BOND FUNCTIONALIZATION; FACILE SYNTHESIS; N-OXIDES; RH(III)-CATALYZED SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; DIAZOCARBONYL COMPOUNDS; ASYMMETRIC-SYNTHESIS;

D O I：

10.1039/c6cc08788d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we disclose the first report on the synthesis of oxindole derivatives from acetanilide via Ir(III)-catalyzed intermolecular C-H functionalization with diazotized Meldrum's acid. A broad range of substituted anilides were found to react smoothly under the Ir(III)-catalytic system to afford the corresponding N-protected oxindoles. The N-protecting groups, such as Ac, Bz or Piv, can be easily removed to furnish the oxindole. Various synthetic applications of the synthesized oxindole were also demonstrated.

引用

页码：443 / 446

页数：4

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