SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF ISONIAZID CONDENSED WITH CARBOHYDRATE DERIVATIVES

被引：14
|
作者：
Cardoso, Silvia H. [1 ]
de Assis, Joao Vitor [1 ]
de Almeida, Mauro V. [1 ]
Lourenco, Maria Cristina S. [2 ]
Vicente, Felipe R. C. [2 ]
de Souza, Marcus V. N. [2 ]
机构：
[1] Univ Fed Juiz de Fora, Inst Ciencias Exatas, Dept Quim, BR-36036330 Juiz De Fora, MG, Brazil
[2] Fundacao Oswaldo Cruz, BR-21041250 Rio De Janeiro, Brazil
来源：
QUIMICA NOVA | 2009年 / 32卷 / 06期
关键词：
isoniazid analogs; carbohydrates; antimycobacterial activity; ALAMAR BLUE ASSAY; MYCOBACTERIUM-TUBERCULOSIS; SUSCEPTIBILITY; FUTURE; AGENTS; TARGET; DRUGS;
D O I：
10.1590/S0100-40422009000600038
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in mu g/mL. Several compounds exhibited antitubercular activity (0.31-3.12 mu g/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.
引用
收藏
页码：1557 / 1560
页数：4
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