Porphyrin-Catalyzed Oxidation of N-Substituted Tetrahydroisoquinolines to Dihydroisoquinolones

被引：7
|
作者：
Li, Ao [1 ]
Pan, Bin [2 ]
Mu, Chao [1 ]
Wang, Na [2 ]
Li, Yu-Long [1 ]
Ouyang, Qin [2 ]
机构：
[1] Sichuan Univ Sci & Engn, Coll Chem & Environm Engn, Zigong 643000, Peoples R China
[2] Third Mil Med Univ, Coll Pharm, Chongqing 400038, Peoples R China
来源：
SYNLETT | 2021年 / 32卷 / 07期
基金：
国家重点研发计划;
关键词：
photocatalysis; oxidation; porphyrins; zinc catalysis; dihydroisoquinolones; SUPPORTED GOLD NANOPARTICLES; AEROBIC OXIDATION; BENZYLIC AMINES; CYCLIC AMINES; ADIPIC ACID; IN-VITRO; CYCLIZATION; HEMOGLOBIN; ASCORBATE; LACTAMS;
D O I：
10.1055/a-1345-3491
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A visible-light-induced direct alpha-oxygenation of N-substituted 1,2,3,4-tetrahydroisoquinoline derivatives has been successfully developed. Tetraphenylporphyrinatozinc(II) has been identified as an effective and inexpensive photocatalyst for this transformation with a wide range of substrates. This protocol provides a convenient route to the desired products in moderate to good yields at room temperature under air.
引用
收藏
页码：679 / 684
页数：6
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