Potentiation of the insulinotropic and hypoglycemic action of gliquidone by succinic acid esters

被引：7
|
作者：
GarciaMartinez, JA
VillanuevaPenacarrillo, ML
Valverde, I
Bjorkling, F
Malaisse, WJ
机构：
[1] FDN JIMENEZ DIAZ,E-28040 MADRID,SPAIN
[2] LEO PHARMACEUT PROD,DK-2750 BALLERUP,DENMARK
[3] FREE UNIV BRUSSELS,EXPT MED LAB,B-1070 BRUSSELS,BELGIUM
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 325卷 / 01期
关键词：
succinic acid monoethyl ester; succinic acid monopropyl ester; succinic acid monoisopropyl ester; gliquidone; insulin secretion; HYPERGLYCEMIC RATS; ANESTHETIZED RATS; DIMETHYL ESTER; METHYL-ESTERS; D-GLUCOSE; GLIBENCLAMIDE; STIMULATION; ENHANCEMENT; GLIMEPIRIDE; SECRETION;
D O I：
10.1016/S0014-2999(97)00099-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The monoethyl, monopropyl and monoisopropyl esters of succinic acid, administered intravenously at the dose of 2 mu mol/g body weight, were found to increase the insulinotropic action of gliquidone (0.2 nmol/g body weight) in anaesthetized rats. The monoisopropyl ester of succinic acid also doubled the hypoglycemic action of gliquidone. These findings indicate that it is possible to design esters of succinic acid that are devoid of the risk of generating methanol by intracellular hydrolysis, and yet susceptible to increase both the insulinotropic and hypoglycemic responses to antidiabetic agents.
引用
收藏
页码：65 / 68
页数：4
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