Recent advances in carbohydrate-based vaccines

被引：93

作者：

Hecht, Marie-Lyn ^{[1
]}

Stallforth, Pierre ^{[1
]}

Silva, Daniel Varon ^{[1
]}

Adibekian, Alexander ^{[1
]}

Seeberger, Peter H. ^{[1
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2009年 / 13卷 / 03期

关键词：

ONE-POT PROTECTION; DE-NOVO SYNTHESIS; MYCOBACTERIUM-TUBERCULOSIS; BACILLUS-ANTHRACIS; ANTICARBOHYDRATE ANTIBODIES; PROTEIN MODIFICATION; CHEMICAL-SYNTHESIS; CONJUGATE VACCINE; GP120; FRAGMENTS; HIV VACCINES;

D O I：

10.1016/j.cbpa.2009.05.127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vaccinations provide an efficient and cost-effective way to combat devastating human diseases. Besides pathogenic protein markers, cell surface carbohydrates from biological sources are widely used as vaccines. Recently, synthetic immunogenic carbohydrate-protein conjugates have been advanced to vaccine candidates. Progress in the chemical synthesis of oligosaccharides and conjugation methods stimulated the development of novel carbohydrate-based vaccine candidates.

引用

页码：354 / 359

页数：6

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