Vitamin D and rheumatoid arthritis: is there a link?

被引：7
|
作者：
Kiran, Gopinath [1 ]
Debashish, Danda [2 ]
机构：
[1] Christian Med Coll & Hosp, Dept Gen Med, Unit 1, Vellore 632004, Tamil Nadu, India
[2] Christian Med Coll & Hosp, Dept Med & Rheumatol 2, Vellore 632004, Tamil Nadu, India
来源：
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | 2008年 / 11卷 / 03期
关键词：
disease modifying agent; immunomodulatory; rheumatoid arthritis; supplementation; 1,25 dihydroxy vitamin D3;
D O I：
10.1111/j.1756-185X.2008.00385.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rheumatoid arthritis predisposes to osteoporosis and most physicians supplement calcium and 1,25 dihydroxy vitamin D3 along with the standard treatment with disease modifying drugs. Advances in the understanding of physiological actions of 1,25 dihydroxy vitamin D3 suggest that this molecule plays an important role in modulating the immune response of the body. Vitamin D receptor has been found in many cells of the immune system including promyelocytes, myelocytes and macrophages. Experiments in animal models of rheumatoid arthritis have shown amelioration of the disease after administration of 1,25 dihydroxy vitamin D3. This article reviews the available data regarding the role of 1,25 dihydoxy vitamin D3 in rheumatoid arthritis.
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收藏
页码：206 / 211
页数：6
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