Repurposing developmental mechanisms in the adult nervous system

被引：4

作者：

Hunyara, John L. ^{[1
]}

Kolodkin, Alex L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Solomon H Snyder Dept Neurosci, Sch Med, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2020年 / 65卷

关键词：

AXON REGENERATION; SONIC HEDGEHOG; SPINAL-CORD; COUP-TFI; STEM-CELLS; NEUROGENESIS; NEURONS; CNS; RECEPTORS; BRAIN;

D O I：

10.1016/j.gde.2020.04.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Molecules and cellular processes important for nervous system development can be repurposed in adulthood for the regulation of adult neurogenesis, synaptic plasticity, and neural regeneration following injury or degeneration. Efforts to recapitulate neural development in order to ameliorate injury or disease are promising, but these often fall short of functional restoration due in part to our incomplete understanding of how these damaged circuits initially developed. Despite these limitations, such strategies provide hope that harnessing developmental mechanisms can restore nervous system functions following damage or disease.

引用

页码：14 / 21

页数：8

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