Synthesis of multisubstituted furans via Cu(I)-catalyzed annulation of ketones with alkynoate under ligand- and additive-free conditions

被引：14

作者：

Luo, Zaigang ^{[1
]}

Fang, Yuyu ^{[1
]}

Zhao, Yu ^{[1
]}

Liu, Peng ^{[2
]}

Xu, Xuemei ^{[1
]}

Feng, Chengtao ^{[1
]}

Li, Zhong ^{[1
]}

He, Jie ^{[1
]}

机构：

[1] AnHui Univ Sci & Technol, Coll Chem Engn, Huainan 232001, Peoples R China

[2] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 07期

基金：

中国国家自然科学基金;

关键词：

EFFICIENT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; POLYSUBSTITUTED FURANS; ALKYNES; CYCLIZATION; DERIVATIVES; ALLENES;

D O I：

10.1039/c5ra23058f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile and efficient annulation strategy for the synthesis of multisubstituted furan derivatives has been achieved under mild conditions. The developed transformation via C(sp(3))-H bond functionalization catalyzed by copper(I) salts using benzoyl peroxide as an external oxidant possess some obvious advantages. This ligand- and additive-free cyclization protocol offers an environmentally friendly and efficient access to biologically important scaffolds from readily available substrates.

引用

页码：5436 / 5441

页数：6

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