RUNX1 mutations in pediatric acute myeloid leukemia are associated with distinct genetic features and an inferior prognosis

被引：13

作者：

Yamato, Genki ^{[1
,2
,3
]}

Shiba, Norio ^{[3
,4
]}

Yoshida, Kenichi ^{[5
]}

Hara, Yusuke ^{[2
,3
]}

Shiraishi, Yuichi ^{[6
]}

Ohki, Kentaro ^{[7
]}

Okubo, Jun ^{[1
]}

Park, Myoung-ja ^{[1
]}

Sotomatsu, Manabu ^{[1
]}

Arakawa, Hirokazu ^{[2
]}

Kiyokawa, Nobutaka ^{[7
]}

Tomizawa, Daisuke ^{[8
]}

Adachi, Souichi ^{[9
]}

Taga, Takashi ^{[10
]}

Horibe, Keizo ^{[3
]}

Miyano, Satoru ^{[6
,11
]}

Ogawa, Seishi ^{[5
,12
]}

Hayashi, Yasuhide ^{[1
,3
,13
]}

机构：

[1] Gunma Childrens Med Ctr, Dept Hematol Oncol, 779 Shimohakoda, Shibukawa, Gunma 3778577, Japan

[2] Gunma Univ, Grad Sch Med, Dept Pediat, Gunma, Japan

[3] Natl Hosp Org Nagoya Med Ctr, Clin Res Ctr, Nagoya, Aichi, Japan

[4] Yokohama City Univ Med, Dept Pediat, Yokohama, Kanagawa, Japan

[5] Kyoto Univ, Grad Sch Med, Dept Pathol & Tumor Biol, Kyoto, Japan

[6] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab DNA Informat Anal, Tokyo, Japan

[7] Natl Res Inst Child Hlth & Dev, Dept Pediat Hematol & Oncol Res, Tokyo, Japan

[8] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Tokyo, Japan

[9] Kyoto Univ, Grad Sch Med, Dept Human Hlth Sci, Kyoto, Japan

[10] Shiga Univ Med Sci, Dept Pediat, Otsu, Shiga, Japan

[11] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Sequence Anal, Tokyo, Japan

[12] Karolinska Inst, Dept Med, Ctr Hematol & Regenerat Med, Stockholm, Sweden

[13] Japanese Red Cross Gunma Blood Ctr, Gunma, Japan

来源：

BLOOD | 2018年 / 131卷 / 20期

关键词：

DNMT3A MUTATIONS; RELEVANCE; THERAPY; RARE; AML;

D O I：

10.1182/blood-2017-11-814442

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：2266 / 2270

页数：7

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