Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

被引：5
|
作者：
Yokogawa, Mariko [1 ]
Muramatsu, Takahiro [1 ]
Takeuchi, Koh [1 ]
Osawa, Masanori [1 ]
Shimada, Ichio [2 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
[2] Natl Inst Adv Ind Sci & Technol, BIRC, Koto Ku, Tokyo 1350064, Japan
来源：
BIOMOLECULAR NMR ASSIGNMENTS | 2009年 / 3卷 / 01期
基金：
日本学术振兴会;
关键词：
Inwardly rectifying potassium channel; GIRK; Ion transport; Tetramer; NMR; TROSY;
D O I：
10.1007/s12104-009-9156-6
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein beta gamma subunits (G beta gamma), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of H-2/C-13/N-15-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.
引用
收藏
页码：125 / 128
页数：4
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