Current Approaches to the Pharmacologic Treatment of Core Symptoms Across the Lifespan of Autism Spectrum Disorder

被引：9

作者：

Pandina, Gahan ^{[1
]}

Ring, Robert H. ^{[2
,3
]}

Bangerter, Abigail ^{[1
]}

Ness, Seth ^{[1
]}

机构：

[1] Janssen Res & Dev LLC, 1125 Trenton Harbouron Rd, Titusville, NJ 08560 USA

[2] Kaerus Biosci Ltd, London, England

[3] 2110 South Eagle Rd,Suite 392, Newtown, PA 18940 USA

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 2020年 / 43卷 / 04期

关键词：

ASD; Autism; Drug development; Therapeutics; Clinical trials; SOCIAL-BEHAVIOR; ENDOCANNABINOID SYSTEM; REPETITIVE BEHAVIORS; EARLY-CHILDHOOD; MOUSE MODEL; CHILDREN; OXYTOCIN; ADOLESCENTS; ADULTS; BRAIN;

D O I：

10.1016/j.psc.2020.08.003

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

There are no approved medications for autism spectrum disorder (ASD) core symptoms. However, given the significant clinical need, children and adults with ASD are prescribed medication off label for core or associated conditions, sometimes based on limited evidence for effectiveness. Recent developments in the understanding of biologic basis of ASD have led to novel targets with potential to impact core symptoms, and several clinical trials are underway. Heterogeneity in course of development, cooccurring conditions, and age-related treatment response variability hampers study outcomes. Novel measures and approaches to ASD clinical trial design will help in development of effective pharmacologic treatments.

引用

页码：629 / +

页数：18

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