A new one-pot three-component condensation reaction for the synthesis of 2,3,4,6-tetrasubstituted pyridines

被引：152
|
作者：
Bagley, MC
Dale, JW
Bower, J
机构：
[1] Cardiff Univ, Dept Chem, Cardiff CF10 3TB, S Glam, Wales
[2] Ribotargets ltd, Cambridge CB1 6GB, England
来源：
CHEMICAL COMMUNICATIONS | 2002年 / 16期
关键词：
D O I：
10.1039/b203900a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The one-pot three-component condensation of a beta-ketoester, ammonia and an alkynone in the presence of a Bronsted or Lewis acid or Amberlyst 15 ion exchange resin provided 2,3,6-trisubstituted or 2,3,4,6-tetrasubstituted pyridines directly in good yield and with total regiocontrol.
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页码：1682 / 1683
页数：2
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