Barbaterpene and Barbatusterol, New Constituents from Plectranthus barbatus Growing in Saudi Arabia

被引:3
|
作者
Amina, Musarat [1 ]
Al Musayeib, Nawal M. [1 ]
Al-Said, Mansour S. [1 ]
Al-Zahrani, Rania A. [1 ]
Ibrahim, Sabrin R. M. [2 ]
Mohamed, Gamal A. [3 ]
机构
[1] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia
[2] Taibah Univ, Coll Pharm, Dept Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawarah 30078, Saudi Arabia
[3] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah 21589, Saudi Arabia
关键词
Plectranthus barbatus; Lamiaceae; triterpene; sterol; barbaterpene; barbatusterol; CUCUMIS-MELO SEEDS; BLEPHARIS-CILIARIS; ANDREWS LAMIACEAE; TRITERPENOIDS; CERAMIDES; PROCERA; STEROL; PLANTS;
D O I
10.2174/1570180814666171120161340
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Background: Plectrantus barbatus Andr. (Lamiaceae) has been used in Hindu and Ayurvedic Indian traditional as well as Brazilian folk medicine for the treatment of several diseases. Chemical investigation of different parts of this plant has led to isolation of essential oil, diterpenes (abietane and labdane), flavonoids, phenolic compounds with interesting biological properties. The objective of study was to isolate pure new chemical entities from aerial parts of P. barbatus. Methods: Different chromatographic methods were used to isolate pure compounds from the ethyl acetate soluble fraction of ethanol extract of P. barbatus. Their chemical structures were verified utilizing various spectroscopic experiments such as NMR (1H, 13C, COSY, HMBC, HSQC), Mass spectrometry (EI-MS experiments) as well as by chemical degradation. Results: The chemical investigation of ethyl acetate soluble fraction of the ethanol extract of P. barbatus resulted in six compounds, barbaterpene (2) (2`R-hydroxydocosanoylursa-12-en-3 beta-ol) and barbatusterol (3) new to the literature along with four known compounds, stigmasterol (1), sugiol (4), 11,14-dihydroxy-8,11,13-abietatrien-7-one (5), and caffeic acid (6). Conclusion: Two new metabolites: barbaterpene (2) (2` R-hydroxydocosanoylursa-12-en-3 beta-ol) and barbatusterol (3) (3 beta, 5 alpha-dihydroxy-stigma-7(8), 22-diene), in addition to stigmasterol (1), sugiol (4), 11,14-dihydroxy-8,11,13-abietatrien-7-one (5), and caffeic acid (6) were separated from the aerial parts of P. barbatus.
引用
收藏
页码:851 / 856
页数:6
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