Thyroid-stimulating hormone reference ranges for moderate-to-late preterm infants

被引：5
|
作者：
Kaluarachchi, Dinushan C. [1 ]
Nicksic, Victoria M. [1 ]
Allen, David B. [1 ]
Eickhoff, Jens C. [2 ]
Dawe, Sandra J. [3 ]
Baker, Mei W. [1 ,3 ]
机构：
[1] Univ Wisconsin, Dept Pediat, Madison, WI 53706 USA
[2] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin State Lab Hyg, Madison, WI USA
来源：
JOURNAL OF PERINATOLOGY | 2021年 / 41卷 / 11期
关键词：
HYPOTHYROIDISM; OUTCOMES;
D O I：
10.1038/s41372-020-00895-6
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Background: Identifying congenital hypothyroidism through newborn screening (NBS) is higher among moderate-to-late preterm (MLPT) infants. Currently, the same thyroid-stimulating hormone (TSH) cutoffs are used for term and preterm infants. TSH reference ranges for MLPT infants are not currently available. Objective: To determine TSH reference ranges for MLPT infants. Methods: We analyzed 10,987 TSH levels on NBS samples performed on 8499 MLPT infants born between 32 and 36 weeks gestation. Results: TSH median, 5th, 25th, 75th, 95th, and 99th percentiles were defined from day 1 until day 14 of life. TSH levels gradually decreased after birth and reached a plateau around day 6. Conclusion: Using a state-wide cohort, we constructed TSH reference charts from day 1 until day 14 for MLPT infants. Relationship between age-adjusted TSH percentiles and long-term neurodevelopmental outcomes should be determined in future studies to define optimal TSH cutoffs for MLPT infants.
引用
收藏
页码：2664 / 2667
页数：4
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