In vitro Anti-Influenza Viral Activities of Constituents from Caesalpinia sappan

被引：77

作者：

Liu, Ai-Lin ^{[2
,3
]}

Shu, Shi-Hui ^{[2
,3
]}

Qin, Hai-Lin ^{[2
,3
]}

Lee, Simon Ming Yuen ^{[1
]}

Wang, Yi-Tao ^{[1
]}

Du, Guan-Hua ^{[2
,3
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, Taipa, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

来源：

PLANTA MEDICA | 2009年 / 75卷 / 04期

关键词：

Caesalpinia sappan; Leguminosae; influenza virus; neuraminidase; sappanchalcone;

D O I：

10.1055/s-0028-1112208

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 mu g/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 mu g/mL, respectively.

引用

页码：337 / 339

页数：3

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