In vitro Anti-Influenza Viral Activities of Constituents from Caesalpinia sappan

被引：79
|
作者：
Liu, Ai-Lin [2 ,3 ]
Shu, Shi-Hui [2 ,3 ]
Qin, Hai-Lin [2 ,3 ]
Lee, Simon Ming Yuen [1 ]
Wang, Yi-Tao [1 ]
Du, Guan-Hua [2 ,3 ]
机构：
[1] Univ Macau, Inst Chinese Med Sci, Taipa, Peoples R China
[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
[3] Peking Union Med Coll, Beijing 100021, Peoples R China
来源：
PLANTA MEDICA | 2009年 / 75卷 / 04期
关键词：
Caesalpinia sappan; Leguminosae; influenza virus; neuraminidase; sappanchalcone;
D O I：
10.1055/s-0028-1112208
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 mu g/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 mu g/mL, respectively.
引用
收藏
页码：337 / 339
页数：3
相关论文
共 50 条
  • [1] In Vitro Anti-influenza Viral Activities of Stilbenoids from the Lianas of Gnetum pendulum
    Liu, Ai-Lin
    Yang, Fan
    Zhu, Mian
    Zhou, Dan
    Lin, Mao
    Lee, Simon Ming-Yuen
    Wang, Yi-Tao
    Du, Guan-Hua
    [J]. PLANTA MEDICA, 2010, 76 (16) : 1874 - 1876
  • [2] Chemical constituents from heartwoods of Caesalpinia sappan with antiplatelet aggregation activities
    Ji, Yu
    Zhang, Ya-qiong
    Liu, Tong-dan
    Xia, Meng-yuan
    Long, Chun-lin
    Wang, Li
    Wang, Yue-hu
    Kong, Yi
    [J]. CHINESE HERBAL MEDICINES, 2019, 11 (04) : 423 - 428
  • [3] Chemical constituents from heartwoods of Caesalpinia sappan with antiplatelet aggregation activities
    Yu Ji
    Yaqiong Zhang
    Tongdan Liu
    Mengyuan Xia
    Chunlin Long
    Li Wang
    Yuehu Wang
    Yi Kong
    [J]. Chinese Herbal Medicines, 2019, 11 (04) : 423 - 428
  • [4] Chemical constituents from heartwoods of Caesalpinia sappan with antiplatelet aggregation activities
    Yu Ji
    Ya-qiong Zhang
    Tong-dan Liu
    Meng-yuan Xia
    Chun-lin Long
    Li Wang
    Yue-hu Wang
    Yi Kong
    [J]. Chinese Herbal Medicines, 2019, (04) : 423 - 428
  • [5] Antioxidant Activity In Vitro of Three Constituents from Caesalpinia sappan L
    胡珺
    闫晓玲
    王伟
    吴昊
    花雷
    杜力军
    [J]. Tsinghua Science and Technology, 2008, (04) : 474 - 479
  • [6] Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities
    Dong, Jian-Yong
    Ma, Xi-Yan
    Cai, Xiao-Qin
    Yan, Peng-Cheng
    Yue, Lei
    Lin, Chen
    Shao, Wei-Wei
    [J]. PHYTOCHEMISTRY, 2013, 85 : 122 - 128
  • [7] Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities
    Jeong, Hyung Jae
    Ryu, Young Bae
    Park, Su-Jin
    Kim, Jang Hoon
    Kwon, Hyung-Jun
    Kim, Jin Hyo
    Park, Ki Hun
    Rho, Mun-Chual
    Lee, Woo Song
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (19) : 6816 - 6823
  • [8] Chemical constituents from Canarium album Raeusch and their anti-influenza A virus activities
    Yang, Luo-Ping
    Gu, Xiao-Long
    Chen, Jin-Xiang
    Yang, Jie
    Tan, Sui-Yi
    Duan, Wen-Jun
    [J]. JOURNAL OF NATURAL MEDICINES, 2018, 72 (03) : 808 - 815
  • [9] Chemical constituents from Canarium album Raeusch and their anti-influenza A virus activities
    Luo-Ping Yang
    Xiao-Long Gu
    Jin-Xiang Chen
    Jie Yang
    Sui-Yi Tan
    Wen-Jun Duan
    [J]. Journal of Natural Medicines, 2018, 72 : 808 - 815
  • [10] Chemical constituents from Melicope pteleifolia leaves and their anti-influenza virus activities
    Nguyen, N. H.
    Ha, T. K. Q.
    Oh, W. K.
    [J]. PLANTA MEDICA, 2016, 82
12345