Crystal Structure of HAV 3C Protease Complexed with a β-lactone Inhibitor: a New Crystal Form of HAV 3C and Its Application for Studying Enzyme-inhibitor Interaction

被引：1
|
作者：
Yin, Jiang [1 ]
Bergmann, Ernst M. [1 ,3 ]
Cherney, Maia M. [1 ]
Lall, Manjinder S. [2 ]
Jain, Rajendra P. [2 ]
Vederas, John C. [2 ]
James, Michael N. G. [1 ,3 ,4 ]
机构：
[1] CIHR, Grp Prot Struct & Funct, Dept Biochem, Ottawa, ON T6G2H7, Canada
[2] CIHR, Grp Prot Struct & Funct, Dept Chem, Ottawa, ON T6G2G2, Canada
[3] Univ Alberta, Alberta Synchrotron Inst, Edmonton, AB T6G2H7, Canada
[4] Canadian Res Chair Prot Struct & Funct, Edmonton, AB, Canada
来源：
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES | 2005年 / 61卷
关键词：
hepatitis; protease; inhibitor;
D O I：
10.1107/S0108767305091233
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
P.04.02.11
引用
收藏
页码：C206 / C206
页数：1
相关论文
共 50 条
  • [21] Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor
    Wang, Yaxin
    Cao, Lin
    Zhai, Yangyang
    Yin, Zheng
    Sun, Yuna
    Shang, Luqing
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (07)
  • [22] CRYSTAL STRUCTURE OF HUMAN ERYTHROCYTE CARBONIC ANHYDRASE C .3. MOLECULAR STRUCTURE OF ENZYME AND OF ONE ENZYME-INHIBITOR COMPLEX AT 5.5 A RESOLUTION
    FRIDBORG, K
    KANNAN, KK
    LILJAS, A
    LUNDIN, J
    STRANDBERG, B
    STRANDBERG, R
    TILANDER, B
    WIREN, G
    JOURNAL OF MOLECULAR BIOLOGY, 1967, 25 (03) : 505 - +
  • [23] Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease
    Jeong, Joo Young
    Sperry, Jonathan
    Taylor, John A.
    Brimble, Margaret A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 87 : 220 - 227
  • [24] POTENT INHIBITOR OF THE HUMAN RHINOVIRUS (HRV) 3C PROTEASE CONTAINING A BACKBONE MODIFIED GLUTAMINE
    SHAM, HL
    ROSENBROOK, W
    KATI, W
    BETEBENNER, DA
    WIDEBURG, NE
    SALDIVAR, A
    PLATTNER, JJ
    NORBECK, DW
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1995, (09): : 1081 - 1082
  • [25] Fine structure of the valence band top in a 3C BN crystal with a nanopore
    Ilyasov, VV
    Nikiforov, IY
    Ilyasov, YV
    PHYSICS OF THE SOLID STATE, 2001, 43 (04) : 621 - 624
  • [26] Fine structure of the valence band top in a 3C BN crystal with a nanopore
    V. V. Ilyasov
    I. Ya. Nikiforov
    Yu. V. Ilyasov
    Physics of the Solid State, 2001, 43 : 621 - 624
  • [27] Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease
    Ma, Yuying
    Li, Linfeng
    He, Shuai
    Shang, Chengyou
    Sun, Yang
    Liu, Ning
    Meek, Thomas D.
    Wang, Yaxin
    Shang, Luqing
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (13) : 6146 - 6162
  • [28] Novel triterpene sulfates from Fusarium compactum using a rhinovirus 3C protease inhibitor screen
    Brill, GM
    Kati, WM
    Montgomery, D
    Karwowski, JP
    Humphrey, PE
    Jackson, M
    Clement, JJ
    Kadam, S
    Chen, RH
    McAlpine, JB
    JOURNAL OF ANTIBIOTICS, 1996, 49 (06): : 541 - 546
  • [29] In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease
    Patick, AK
    Binford, SL
    Brothers, MA
    Jackson, RL
    Ford, CE
    Diem, MD
    Maldonado, F
    Dragovich, PS
    Zhou, R
    Prins, TJ
    Fuhrman, SA
    Meador, JW
    Zalman, LS
    Matthews, DA
    Worland, ST
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (10) : 2444 - 2450
  • [30] Iridium-Catalysed C-H Borylation Facilitates a Total Synthesis of the HRV 3C Protease Inhibitor (±)-Thysanone
    Schuenemann, Katrin
    Furkert, Daniel P.
    Connelly, Stephen
    Fraser, John D.
    Sperry, Jonathan
    Brimble, Margaret A.
    SYNLETT, 2014, 25 (04) : 556 - 558
12345