SOLVENT FREE N-BOC PROTECTION OF AMINES USING AMBERLYSTR A 21 SOLID BASE RESIN AS A REUSABLE HETEROGENEOUS CATALYST

被引：0

作者：

Tekale, Sunil U. ^{[1
]}

Kauthale, Sushama S. ^{[1
]}

Pawar, Rajendra P. ^{[1
]}

机构：

[1] Deogiri Coll, Dept Chem, Aurangabad 431005, Maharashtra, India

来源：

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2013年 / 58卷 / 01期

关键词：

Amberlyst(R) A 21; Amine; t-butyl dicarbonate; Carbamate; Heterogeneous catalyst; TERT-BUTOXYCARBONYLATION; EFFICIENT; ACID;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient, environmentally benign, highly facile and convenient synthetic protocol for the selective t-butyl carboxylation of aliphatic, aromatic and heterocyclic amines using Amberlyst(R) A 21 catalyst; a mild basic solid resin under solvent free conditions is reported. This method explores several advantages such as reusability of the heterogeneous catalyst, cleaner reaction profile, mild and solvent free system, short reaction time, operational simplicity, high conversions, excellent product yields and low cost of the catalyst. Furthermore since the catalyst is mild basic, decomposition of the carbamate formed is not observed if the reaction is continued for prolonged time as in the case of Lewis acid catalyzed N-Boc protection. This makes the present protocol a useful and attractive for N-Boc protection of amines.

引用

页码：1619 / 1623

页数：5

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