The epitheliome: agent-based modelling of the social behaviour of cells

被引：118
|
作者：
Walker, DC [1 ]
Southgate, J
Hill, G
Holcombe, A
Hose, DR
Wood, SM
Mac Neil, S
Smallwood, RH
机构：
[1] Univ Sheffield, Dept Comp Sci, Sheffield S10 2TN, S Yorkshire, England
[2] Univ Sheffield, Royal Hallamshire Hosp, Sheffield S10 2JF, S Yorkshire, England
[3] Univ York, Dept Biol, York YO10 5DD, N Yorkshire, England
[4] Univ Sheffield, Dept Mat Engn, Sheffield S10 2TN, S Yorkshire, England
来源：
BIOSYSTEMS | 2004年 / 76卷 / 1-3期
关键词：
self-organizing systems; agent-based modelling; epithelium; cell culture; calcium;
D O I：
10.1016/j.biosystems.2004.05.025
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have developed a new computational modelling paradigm for predicting the emergent behaviour resulting from the interaction of cells in epithelial tissue. As proof-of-concept, an agent-based model, in which there is a one-to-one correspondence between biological cells and software agents, has been coupled to a simple physical model. Behaviour of the computational model is compared with the growth characteristics of epithelial cells in monolayer culture, using growth media with low and physiological calcium concentrations. Results show a qualitative fit between the growth characteristics produced by the simulation and the in vitro cell models. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：89 / 100
页数：12
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