Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells

被引：5

作者：

Xu, Changzhi ^{[1
]}

Yang, Ling ^{[1
]}

Yuan, Yuan ^{[2
]}

Du, Fei ^{[2
]}

Wang, Shumin ^{[1
]}

Wang, Xiangfang ^{[1
]}

Zhu, Lin ^{[1
]}

Zhang, Buchang ^{[1
]}

Weaver, David ^{[1
]}

机构：

[1] Anhui Univ, Inst Hlth Sci, Hefei 230601, Anhui, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 3, Binhu Hosp, Cent Lab, Hefei 230601, Anhui, Peoples R China

来源：

MICROBIAL PATHOGENESIS | 2016年 / 90卷

关键词：

Listeria monocytogenes; CYLD; Apoptosis; NF-KAPPA-B; DEUBIQUITINATING ENZYME; GENE; PATHOGENESIS; INFECTIONS; ACTIVATION; EXPRESSION; RESPONSES; BACTERIAL; MICE;

D O I：

10.1016/j.micpath.2015.10.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Listeria monocytogenes (Lm), a facultative anaerobic gram-positive bacterium, causes listeriosis. Immune cell apoptosis is considered to be one pathogenic factor for listeriosis. As a deubiquitinase, CYLD is an important regulator both in innate immune response and apoptosis by negatively modulating NF-kappa B pathway. However the role of CYLD in Lm induced apoptosis remains unclear. Here we found that CYLD is significantly up-regulated in macrophages upon its infection. There is a moderate decrease in Lm proliferation and apoptotic cells in siRNA-induced CYLD knockdown THP-1 cells. Thereby CYLD may be involved in cell apoptosis mediated by Lm infection and its proliferation. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：50 / 54

页数：5

共 50 条

[31] Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cells
Du, Maotao
Zhang, Zhong
Gao, Tao
BIOLOGICAL RESEARCH, 2017, 50
[32] The inhibition of apoptosis of hepatoma cells induced by HBx is mediated by up-regulation of survivin expression
Li Donghua
Chen Xiaoping
Zhang Wanguang
Current Medical Science, 2003, 23 (4) : 383 - 386
[33] Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cells
Maotao Du
Zhong Zhang
Tao Gao
Biological Research, 50
[34] The Inhibition of Apoptosis of Hepatoma Cells Induced by HBx Is Mediated by Up-regulation of Survivin Expression
李东华
陈孝平
张万广
华中科技大学学报(医学英德文版), 2003, (04) : 383 - 386
[35] APOPTOSIS OF THP-1 MACROPHAGES INDUCED BY PROTOPORPHYRIN IX MEDIATED SONODYNAMIC THERAPY
Xu Haobo
Tian Ye
HEART, 2013, 99 : E79 - E80
[36] Synthesis of Copper-Platinum Nanoparticles Induce Apoptosis in THP-1 cells
Alshatwi, Ali A.
Athinarayanan, Jegan
Periasamy, Vaiyapuri Subbarayan
Prato, Maurizio
2015 IEEE 15TH INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO), 2015, : 1111 - 1113
[37] Regulation of LPS-induced tissue factor expression in human monocytic THP-1 cells by curcumin
Guo, Weimin
Ratnasari, Anita
Li, Jing
Meydani, Mohsen
FASEB JOURNAL, 2009, 23
[38] Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells
Liu, Junhong
Hong, Suli
Feng, Zhiyong
Xin, Yinqiang
Wang, Qi
Fu, Jin
Zhang, Chao
Li, Guilan
Luo, Lan
Yin, Zhimin
CELLULAR IMMUNOLOGY, 2010, 264 (02) : 127 - 134
[39] Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling
Xian, Jingrong
Shao, Huiyuan
Chen, Xianchun
Zhang, Shuaishuai
Quan, Jing
Zou, Qin
Jin, Hongjun
Zhang, Ling
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2016, 12 (02): : 144 - 155
[40] Platelet Microparticles Decrease Daunorubicin-Induced DNA Damage and Modulate Intrinsic Apoptosis in THP-1 Cells
Cacic, Daniel
Nordgard, Oddmund
Meyer, Peter
Hervig, Tor
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (14)

← 1 2 3 4 5 →