Losartan treating podocyte injury induced by Ang II via downregulation of TRPC6 in podocytes

被引：5
|
作者：
Chi-Xianggeng [1 ]
Hu-Bo [2 ]
Yu, S. Y. [3 ]
Yin-Lianghong [2 ]
Meng-Yu [2 ]
Wang-Boxun [2 ]
Yang-Jinsheng [2 ]
Lin-Jiahui [2 ]
Huang-Dexu [2 ]
Chen-lanlan [4 ]
机构：
[1] Southern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
[2] JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Guangzhou, Guangdong, Peoples R China
[4] GongAn Hosp Tradit Chinese Med, Wuhan, HuBei, Peoples R China
来源：
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | 2015年 / 16卷 / 04期
关键词：
Losartan; TRPC6; proteinuria; podocyte; signal pathway; CHANNELS; INHIBITION; FILTRATION; EXPRESSION;
D O I：
10.1177/1470320315573682
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Objective: In this study, we investigated the molecule mechanisms of podocyte injury and proteinuria and the protective effects of losartan. Methods: This study set up three groups: a control group; an Ang II group (Ang II 10(-6) mol/l, Sigma); and a losartan group (losartan 10(-6) mol/l, Sigma). We used RT-PCR assay to detect TRPC6 mRNA expression, and Western blot to detect TRPC6 protein expression. Results: TRPC6 overexpression was the basic change of podocyte injury and proteinuria occurrence. Losartan can treat podocyte injury and proteinuria induced by Ang II via downregulation of TRPC6 in podocytes. Conclusion: These findings maybe provide an ideal drug target for the diagnosis and treatment of acquired glomerular diseases.
引用
收藏
页码：1118 / 1124
页数：7
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