MT1 receptor expression and AA-NAT activity in lymphatic tissue following melatonin administration in male golden hamster

被引:10
|
作者
Vishwas, Dipanshu Kumar [1 ]
Haldar, Chandana [1 ]
机构
[1] Banaras Hindu Univ, Dept Zool, Pineal Res Lab, Varanasi 221005, Uttar Pradesh, India
关键词
Melatonin; AA-NAT activity; Blastogenic response; BM-MNCs; MT1; receptor; BONE-MARROW; CELLS; LYMPHOCYTES; RESPONSES; IMMUNITY; STRESS; PROLIFERATION; MECHANISMS; GAMMA; GLAND;
D O I
10.1016/j.intimp.2014.06.038
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Exogenous melatonin as a marker of the chemical expression of darkness is playing a key role in the synchronization of circadian functions and seasonal biological rhythms. Our study was designed to elucidate whether melatonin treatment can modulate the melatonin synthesis via the rate limiting enzyme arylalkylamine-N-acetyltransferase (AA-NAT) in spleen, thymus and bone marrow thereby the proliferation rate of splenocytes, thymocytes and bone marrow mononuclear cells (BM-MNCs) of golden hamsters. The AA-NAT activity in different lymphoid tissue documented the synthesis of melatonin in those organs. Exogenous melatonin treatment to hamsters enhanced the AA-NAT activity in spleen and thymus along with an increase in the inflammatory response by DTH reactions that could be related to the increased level of interleukin-2 and IFN-gamma by T lymphocytes in serum/culture medium, proliferation rate and expression of melatonin membrane receptor MT1. Thus, the relevance of melatonin synthesis by lymphatic tissues might be maintaining surveillance and local defence responses. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:258 / 265
页数:8
相关论文
共 50 条
  • [21] Endogenous and Exogenous Melatonin Exposure Attenuates Hepatic MT1 Melatonin Receptor Protein Expression in Rat
    Mathes, Alexander M.
    Heymann, Paul
    Ruf, Christian
    Huhn, Ragnar
    Hinkelbein, Jochen
    Volk, Thomas
    Fink, Tobias
    ANTIOXIDANTS, 2019, 8 (09)
  • [22] MT1 melatonin receptor mRNA expressing cells in the pars tuberalis of the European hamster:: Effect of photoperiod
    Dardente, H
    Klosen, P
    Pévet, P
    Masson-Pévet, M
    JOURNAL OF NEUROENDOCRINOLOGY, 2003, 15 (08) : 778 - 786
  • [23] Expression of melatonin receptor (MT1) and interaction between melatonin and estrogen in endometrial cancer cell line
    Watanabe, Mari
    Kobayashi, Yoichi
    Takahashi, Noriyuki
    Kiguchi, Kazushige
    Ishizuka, Bunpei
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2008, 34 (04) : 567 - 573
  • [24] The Expression of MT1 Melatonin Receptor and Ki-67 Antigen in Melanoma Malignum
    Danielczyk, Karolina
    Dziegiel, Piotr
    ANTICANCER RESEARCH, 2009, 29 (10) : 3887 - 3895
  • [25] Expression of melatonin receptor MT1 in cells of human invasive ductal breast carcinoma
    Jablonska, Karolina
    Pula, Bartosz
    Zemla, Agata
    Owczarek, Tomasz
    Wojnar, Andrzej
    Rys, Janusz
    Ambicka, Aleksandra
    Podhorska-Okolow, Marzena
    Ugorski, Maciej
    Dziegiel, Piotr
    JOURNAL OF PINEAL RESEARCH, 2013, 54 (03) : 334 - 345
  • [26] The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system
    Uz, T
    Arslan, AD
    Kurtuncu, M
    Imbesi, M
    Akhlsaroglu, M
    Dwivedi, Y
    Pandey, GN
    Manev, H
    MOLECULAR BRAIN RESEARCH, 2005, 136 (1-2): : 45 - 53
  • [27] Polymorphism of MT1 melatonin gene receptor and reproductive activity in Sarda breed sheep
    Carcangiu, V.
    Vacca, G. M.
    Mura, M. C.
    Dettori, M. L.
    Pazzola, M.
    Luridiana, S.
    Marchi, B.
    Bini, P. P.
    REPRODUCTION IN DOMESTIC ANIMALS, 2007, 42 : 141 - 141
  • [28] MT1 AND MT2 MELATONIN RECEPTOR EXPRESSION AND IN VITRO MELATONIN EFFECT ON THE PHA-DEPENDENT ACTIVATION OF HUMAN PBMC
    Georgiev, Georgi N.
    Mourdjeva, Milena
    Oreshkova, Tsvetelina
    Pankov, Roumen
    Konakchieva, Rossitza
    COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, 2019, 72 (11): : 1500 - 1506
  • [29] Expression of MT1 and melatonin related receptor (H9) in adult rat testis
    De Rienzo, G
    Aniello, F
    Ferrara, D
    Minucci, S
    Serino, I
    D'istria, M
    PERSPECTIVE IN COMPARATIVE ENDOCRINOLOGY: UNITY AND DIVERSITY, 2001, : 1075 - 1079
  • [30] Daily and circadian expression patterns of MT1 melatonin receptor mRNA in the rat pars tuberalis
    Guerrero, HY
    Gauer, F
    Pevet, P
    Masson-Pevet, M
    MELATONIN AFTER FOUR DECADES: AN ASSESSMENT OF ITS POTENTIAL, 1999, 460 : 175 - 179