Ceramide-induced vasorelaxation - An inhibitory action on protein kinase C

被引：14
|
作者：
Johns, DG
Jin, JS
Wilde, DW
Webb, RC
机构：
[1] Univ Michigan, Dept Physiol, Ann Arbor, MI 48109 USA
[2] Natl Def Med Ctr, Dept Physiol, Taipei, Taiwan
来源：
GENERAL PHARMACOLOGY | 1999年 / 33卷 / 05期
关键词：
ceramide; vascular smooth muscle; vasorelaxation; sphingosine; okadaic acid; oleoylethanolamine;
D O I：
10.1016/S0306-3623(99)00038-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Experiments were designed to examine the role of sphingosine, PP2A phosphatases, and protein kinase C (PKC) inhibition in mediating the vasodilatory effects of ceramide in rat thoracic aorta. Sphingosine did not cause vasorelaxation, and oleoylethanolamine, a ceramidase inhibitor, did not affect sphingomyelinase-induced relaxation. Okadaic acid potentiated the relaxation response to ceramide. These observations rule out involvement of sphingosine and PP2A phosphatases in mediating ceramide-induced relaxation. Sphingomyelinase attenuated contractile and single-cell intracellular calcium responses to phorbol ester. Chelerythrine incubation potentiated the relaxation response to ceramide. These observations support a role for PKC inhibition in mediating the vasodilatory effects of ceramide. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：415 / 421
页数：7
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