The neurotrophic hepatocyte growth factor induces protolerogenic human dendritic cells

被引：10
|
作者：
Molnarfi, Nicolas [1 ,2 ,3 ]
Benkhoucha, Mandia [1 ,2 ,3 ]
Juillard, Catherine [1 ,2 ]
Bjarnadottir, Kristbjoerg [1 ,2 ,3 ]
Lalive, Patrice H. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Hosp Geneva, Dept Clin Neurosci, Div Neurol, Unit Neuroimmunol & Multiple Sclerosis, CH-1211 Geneva 14, Switzerland
[2] Fac Med, Geneva, Switzerland
[3] Univ Geneva, Dept Pathol & Immunol, Fac Med, CH-1211 Geneva 4, Switzerland
[4] Univ Hosp Geneva, Dept Genet & Lab Med, Lab Med Serv, CH-1211 Geneva 14, Switzerland
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 267卷 / 1-2期
基金：
瑞士国家科学基金会;
关键词：
Multiple sclerosis (MS); Hepatocyte growth factor; Monocyte-derived dendritic cells; Immune regulation; Neuroinflammation; MULTIPLE-SCLEROSIS; MONOCYTES; RECOVERY; IL-23; BETA;
D O I：
10.1016/j.jneuroim.2013.12.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatocyte growth factor (HGF) limits mouse autoimmune neuroinflammation by promoting the development of tolerogenic dendritic cells (DCs). Given the role played by DCs in the establishment of immunological tolerance, agents that coerce DCs to adopt a protolerogenic function are currently under investigation for multiple sclerosis (MS) therapy. Here, we studied the immunomodulatory effects of HGF on DCs derived from human monocytes. DCs differentiated in the presence of HGF adopt a protolerogenic phenotype with increased ability to generate regulatory T cells, a property that might be exploited therapeutically in T cell-mediated immune disorders such as MS. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：105 / 110
页数：6
相关论文
共 50 条
  • [21] Selective induction of nerve growth factor and brain-derived neurotrophic factor by LPS and allergen in dendritic cells
    Noga, O.
    Peiser, M.
    Altenaehr, M.
    Schmeck, B.
    Wanner, R.
    Dinh, Q. T.
    Hanf, G.
    Suttorp, N.
    CLINICAL AND EXPERIMENTAL ALLERGY, 2008, 38 (03): : 473 - 479
  • [22] Hepatocyte growth factor enhances MMP activity in human endothelial cells
    Wang, H
    Keiser, JA
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 272 (03) : 900 - 905
  • [23] Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor
    Holt, Randi Utne
    Baykov, Vadim
    Ro, Torstein Baade
    Brabrand, Sigmund
    Waage, Anders
    Sundan, Anders
    Borset, Magne
    HAEMATOLOGICA, 2005, 90 (04) : 479 - 488
  • [24] Evidence for a functional Hepatocyte Growth Factor receptor in human mesangial cells
    Kallincos, NC
    Pollard, AN
    Couper, JJ
    REGULATORY PEPTIDES, 1998, 74 (2-3) : 137 - 142
  • [25] Hepatocyte growth factor scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons
    Ebens, A
    Brose, K
    Leonardo, ED
    Hanson, MG
    Bladt, F
    Birchmeier, C
    Barres, BA
    TessierLavigne, M
    NEURON, 1996, 17 (06) : 1157 - 1172
  • [26] Basic fibroblast growth factor stimulates hepatocyte growth factor scatter factor secretion by human mesenchymal cells
    Roletto, F
    Galvani, AP
    Cristiani, C
    Valsasina, B
    Landonio, A
    Bertolero, F
    JOURNAL OF CELLULAR PHYSIOLOGY, 1996, 166 (01) : 105 - 111
  • [27] Hepatocyte growth factor (HGF) induces epithelial mesenchymal transition and growth in glomerular epithelial cells.
    Gregorini, M
    Rampino, T
    Camussi, G
    Conaldi, PG
    Soccio, G
    Maggio, M
    Guidetti, C
    Marasa, M
    Dal Canton, A
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 : 168A - 168A
  • [28] Hepatocyte growth factor promotes motor neuron survival and synergizes with ciliary neurotrophic factor
    Wong, VV
    Glass, DJ
    Arriaga, R
    Yancopoulos, GD
    Lindsay, RM
    Conn, G
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (08) : 5187 - 5191
  • [29] Expression of hepatocyte growth factor in frozen human RPE cells and effects of low molecular weight heparin (Fragmin) on hepatocyte growth factor
    Wang, F
    Tao, XF
    Gu, Q
    Xu, X
    Zhang, X
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 : U84 - U84
  • [30] Hepatocyte growth factor is a survival factor for endothelial cells and is expressed in human atherosclerotic plaques
    Ma, H
    Calderon, TM
    Fallon, JT
    Berman, JW
    ATHEROSCLEROSIS, 2002, 164 (01) : 79 - 87
12345