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Hepatitis C and treatment with pegylated interferon and ribavirin

被引：6
|
作者：
Gotto, J [1 ]
Dusheiko, GM [1 ]
机构：
[1] UCL Royal Free Hosp, Royal Free & Univ Coll, Sch Med, Ctr Hepatol, London NW3 2PF, England
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2004年 / 36卷 / 10期
关键词：
hepatitis C; pegylated interferon; lymphocytes;
D O I：
10.1016/j.biocel.2004.03.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepatitis C is a hepatotropic RNA virus with a propensity to cause chronic infection, causing a worldwide burden of chronic hepatitis, cirrhosis and hepatocellular carcinoma. Both viral elimination and hepatocellular damage are thought to be immune mediated with T-helper and cytotoxic T-lymphocytes central to these events. A delay in the onset of adaptive immunity following infection indicates that a defect in the innate immune response may lead to viral persistence with a combination of other mechanisms subsequently contributing. Antiviral therapy based on interferon-alpha leads to resolution of disease in approximately 50% of patients. Specific anti-hepatitis C anti-viral drugs are being developed. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1874 / 1877
页数：4
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